
Global Sildenafil CAS 139755-83-2 Market Insights, Size, and Forecast By Formulation (Tablets, Injectables, Oral Solutions), By Distribution Channel (Online Pharmacies, Retail Pharmacies, Hospital Pharmacies), By End User (Hospitals, Clinics, Homecare Settings), By Application (Erectile Dysfunction, Pulmonary Hypertension, Altitude Sickness), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), Key Companies, Competitive Analysis, Trends, and Projections for 2026-2035
Key Market Insights
Global Sildenafil CAS 139755-83-2 Market is projected to grow from USD 2.15 Billion in 2025 to USD 3.48 Billion by 2035, reflecting a compound annual growth rate of 6.2% from 2026 through 2035. The Sildenafil market, encompassing the active pharmaceutical ingredient for various therapeutic applications, is defined by its role in treating conditions such as erectile dysfunction and pulmonary arterial hypertension. This growth is primarily fueled by a confluence of factors, including the rising global prevalence of chronic diseases contributing to sexual dysfunction, increasing awareness and reduced social stigma associated with seeking treatment for these conditions, and the expanding geriatric population. Furthermore, the expiration of key patents has led to the proliferation of generic Sildenafil, making the drug more accessible and affordable, thereby expanding its market reach. The dominant application segment, erectile dysfunction, continues to hold a significant majority share, underscoring its foundational role in market dynamics. The market's segmentation by application, formulation (e.g., tablets, oral suspensions), distribution channel (e.g., hospital pharmacies, retail pharmacies, online pharmacies), and end user (e.g., hospitals, clinics, homecare settings) illustrates its intricate structure and diverse avenues for access.
Global Sildenafil CAS 139755-83-2 Market Value (USD Billion) Analysis, 2025-2035

2025 - 2035
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Key trends shaping the Sildenafil market include the growing adoption of telehealth services for consultations and prescriptions, which has significantly enhanced patient convenience and privacy. There is also an emerging interest in combination therapies and novel drug delivery systems designed to improve efficacy and reduce side effects. However, the market faces restraints such as the potential for misuse and illicit sales, stringent regulatory landscapes in certain regions impacting new product approvals, and the availability of alternative treatments, including herbal remedies and medical devices. Nevertheless, significant market opportunities exist in the research and development of Sildenafil derivatives for new therapeutic indications beyond its traditional uses, particularly in areas like cardiovascular health and neurological disorders. Expanding into emerging markets with underdeveloped healthcare infrastructure and increasing disposable incomes also presents a fertile ground for growth.
North America currently stands as the dominant region in the global Sildenafil market, driven by high healthcare expenditure, established regulatory frameworks, strong pharmaceutical research capabilities, and a high prevalence of target conditions. This region benefits from robust awareness campaigns and a greater acceptance of pharmaceutical interventions for conditions like erectile dysfunction. Conversely, the Asia Pacific region is poised for the fastest growth, propelled by its enormous and aging population, rapidly improving healthcare infrastructure, increasing healthcare spending, and a growing middle class with greater access to and willingness to pay for treatments. Key players such as Mylan, Hikma Pharmaceuticals, Sandoz, Torrent Pharmaceuticals, Aurobindo Pharma, Sun Pharmaceutical Industries, Teva Pharmaceuticals, Pfizer, Cipla, and Recordati are actively engaged in competitive strategies including strategic collaborations, product portfolio expansion, and geographical penetration to solidify their market positions and capitalize on these growth opportunities. Their focus often revolves around developing cost-effective generic versions and expanding their reach through robust distribution networks.
Quick Stats
Market Size (2025):
USD 2.15 BillionProjected Market Size (2035):
USD 3.48 BillionLeading Segment:
Erectile Dysfunction (87.4% Share)Dominant Region (2025):
North America (38.2% Share)CAGR (2026-2035):
6.2%
What is Sildenafil CAS 139755-83-2?
Sildenafil CAS 139755-83-2 refers to the chemical compound sildenafil, identified by its unique Chemical Abstracts Service registry number. It is a pharmaceutical active ingredient, specifically a phosphodiesterase type 5 PDE5 inhibitor. Its core concept involves blocking the enzyme PDE5, leading to increased levels of cyclic guanosine monophosphate cGMP. This mechanism primarily causes vasodilation, or the widening of blood vessels. Its significance lies in its application for treating erectile dysfunction and pulmonary arterial hypertension. The CAS number confirms its specific molecular structure and identity, crucial for pharmaceutical manufacturing, regulation, and research, ensuring purity and consistency in drug production and formulation.
What are the Trends in Global Sildenafil CAS 139755-83-2 Market
Sildenafil Supply Chain Resilience
Telemedicine Driving ED Prescriptions
Innovations in Sildenafil Delivery
Personalized ED Treatment Approaches
Sildenafil Supply Chain Resilience
Sildenafil supply chains are strengthening. Manufacturers are diversifying raw material sources and production locations beyond single points of failure. Increased stockpiling and improved logistical networks mitigate disruptions from geopolitical events, natural disasters, or pandemics. This proactive approach ensures a more consistent and reliable supply of sildenafil globally, fostering greater market stability and accessibility for patients.
Telemedicine Driving ED Prescriptions
Telemedicine's rise makes accessing healthcare easier, including for erectile dysfunction. Virtual consultations allow patients to discuss symptoms and receive prescriptions for sildenafil without an in person doctor's visit. This convenient, private care option removes barriers, leading to increased diagnoses and subsequent ED prescriptions globally, expanding patient reach.
Innovations in Sildenafil Delivery
Innovations in sildenafil delivery focus on improving patient convenience and efficacy. This trend involves developing faster acting oral disintegrating tablets, sublingual films for quicker absorption, and topical gels for targeted delivery. Injectables are also emerging for rapid onset. These advancements aim to enhance patient adherence and broaden treatment options beyond traditional pills, making sildenafil more user friendly and effective across various patient needs.
Personalized ED Treatment Approaches
Patients increasingly seek tailored erectile dysfunction treatments beyond generic pills. This trend emphasizes individualized approaches, considering patient specific health, lifestyle, and preferences. Healthcare providers are offering customized sildenafil dosages, combination therapies, and integrating lifestyle advice. This shift towards personalized care aims for higher efficacy and patient satisfaction, driving demand for innovative sildenafil formulations and service models in the global market.
What are the Key Drivers Shaping the Global Sildenafil CAS 139755-83-2 Market
Rising Prevalence of Erectile Dysfunction (ED)
Patent Expirations and Generic Sildenafil Accessibility
Increasing Awareness and Acceptance of ED Treatments
Aging Global Population and Associated Health Conditions
Rising Prevalence of Erectile Dysfunction (ED)
The growing number of men globally experiencing erectile dysfunction significantly propels sildenafil demand. As ED prevalence increases due to aging populations, chronic diseases, and lifestyle factors, more individuals seek effective treatment. This widespread rise directly translates into higher prescriptions and over the counter purchases of sildenafil, driving market expansion as a primary therapeutic solution for this common condition.
Patent Expirations and Generic Sildenafil Accessibility
Patent expirations for branded sildenafil opened the door for generic manufacturers. This increased accessibility to more affordable generic sildenafil significantly broadened its market reach globally. The availability of lower priced alternatives to the original branded product democratized access for a wider consumer base, boosting overall sales volume and market growth for sildenafil.
Increasing Awareness and Acceptance of ED Treatments
Growing understanding and openness towards erectile dysfunction treatments are significant drivers. Educational campaigns by healthcare professionals and pharmaceutical companies have destigmatized ED, making men more comfortable seeking help. Increased media coverage and online resources also contribute to better patient education and willingness to discuss and address the condition, ultimately boosting demand for solutions like sildenafil. This shift in perception fuels market expansion.
Aging Global Population and Associated Health Conditions
An increasingly older global population significantly fuels the sildenafil market. As people age, the prevalence of conditions like erectile dysfunction rises substantially. Concurrently, age related comorbidities such as cardiovascular disease and diabetes often contribute to sexual health issues, further increasing the demand for sildenafil as an effective and readily available treatment option, driving market expansion.
Global Sildenafil CAS 139755-83-2 Market Restraints
Regulatory Scrutiny and Counterfeit Product Concerns
Stringent regulatory oversight, particularly from agencies like the FDA, imposes significant hurdles. Manufacturers must adhere to rigorous quality control, safety, and efficacy standards for sildenafil products. This process is time-consuming and expensive. Furthermore, the pervasive threat of counterfeit sildenafil, often containing incorrect dosages or harmful ingredients, undermines market trust and poses serious public health risks, requiring constant vigilance and enforcement from both regulators and legitimate producers.
Patent Expiries and Generic Competition
Patent expirations for branded sildenafil unleash generic competition. These lower cost alternatives significantly erode the market share and revenue of original manufacturers. As more generics enter, pricing pressures intensify, leading to a substantial decrease in the average selling price of sildenafil products. This heightened rivalry restricts the growth and profitability of established players, forcing them to innovate or lose market dominance.
Global Sildenafil CAS 139755-83-2 Market Opportunities
Strategic Expansion: Capitalizing on Generic Sildenafil through Telemedicine and DTC Models
Strategic expansion capitalizes on generic sildenafil through telemedicine and direct to consumer models. This powerful opportunity leverages generic drugs affordability with innovative digital health solutions. Telemedicine platforms offer convenient, discreet online consultations and prescriptions for erectile dysfunction patients. Direct to consumer distribution ensures seamless home delivery, completely bypassing traditional pharmacy channels. This strategy facilitates rapid global market penetration, enhancing patient access, privacy, and convenience for a widely needed and sensitive treatment.
Beyond ED: Unlocking Sildenafil's Potential in Novel Therapeutic Applications and Advanced Formulations
The opportunity transcends erectile dysfunction, focusing on sildenafil's broad therapeutic potential. Expanding into novel applications for conditions such as pulmonary arterial hypertension, Raynaud's phenomenon, and other cardiovascular issues offers substantial growth. Developing advanced formulations like sustained release, topical gels, or innovative delivery systems improves efficacy and patient compliance. This strategic diversification, especially in the fast growing Asia Pacific region, unlocks new revenue streams and addresses diverse unmet medical needs globally, fully maximizing sildenafil's pharmacological capabilities.
Global Sildenafil CAS 139755-83-2 Market Segmentation Analysis
Key Market Segments
By Application
- •Erectile Dysfunction
- •Pulmonary Hypertension
- •Altitude Sickness
By Formulation
- •Tablets
- •Injectables
- •Oral Solutions
By Distribution Channel
- •Online Pharmacies
- •Retail Pharmacies
- •Hospital Pharmacies
By End User
- •Hospitals
- •Clinics
- •Homecare Settings
Segment Share By Application
Share, By Application, 2025 (%)
- Erectile Dysfunction
- Pulmonary Hypertension
- Altitude Sickness

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Why is Erectile Dysfunction dominating the Global Sildenafil CAS 139755-83-2 Market by application?
Erectile Dysfunction holds the overwhelming majority share of the sildenafil market because it addresses a widespread condition with significant patient awareness and an established treatment pathway. The drug’s efficacy and relatively accessible nature have positioned it as a primary solution for this condition, driving consistent demand across various demographics. While pulmonary hypertension and altitude sickness are important applications, their prevalence and market penetration are considerably smaller in comparison.
How do formulation and end user segments influence market dynamics for Sildenafil CAS 139755-83-2?
Tablets likely represent the dominant formulation due to their convenience, ease of administration, and cost effectiveness for long term use, particularly in homecare settings. Injectables and oral solutions cater to specific patient needs or acute care scenarios, but do not rival the broad appeal of tablets. Furthermore, homecare settings are crucial end users as many conditions treated by sildenafil are chronic, allowing patients to manage their treatment privately and conveniently, underscoring the importance of accessible formulations.
What role do distribution channels play in the accessibility and reach of Sildenafil CAS 139755-83-2?
Online pharmacies are increasingly vital, offering discretion and convenience for purchasing sildenafil, which can be a sensitive topic for many individuals. This channel expands reach beyond traditional retail pharmacies, which still hold a substantial share due to established patient trust and prescription fulfillment processes. Hospital pharmacies serve a more specialized role, primarily for inpatient care or initial prescriptions, but the bulk of ongoing medication supply flows through retail and online platforms to end users in clinics and homecare settings.
What Regulatory and Policy Factors Shape the Global Sildenafil CAS 139755-83-2 Market
The global Sildenafil market navigates a complex regulatory environment. Widespread patent expirations have fostered robust generic competition, necessitating stringent drug approval pathways globally. A significant policy trend is the ongoing transition towards over the counter OTC status in key markets like the UK and Canada, fundamentally reshaping distribution and consumer access while introducing new advertising and labeling requirements. Counterfeit products remain a persistent concern, driving regulatory enforcement and supply chain integrity measures. Regulators worldwide maintain strict oversight on manufacturing quality, advertising claims, and prescription requirements, balancing patient safety with expanding market availability. Online sales platforms also face increasing scrutiny.
What New Technologies are Shaping Global Sildenafil CAS 139755-83-2 Market?
The global sildenafil market is experiencing evolving innovations centered on advanced drug delivery systems. Emerging technologies include orally disintegrating tablets and sublingual films, aiming for faster onset of action and improved patient convenience. Transdermal patches and topical gels are also being explored to potentially minimize systemic side effects. Furthermore, research into combination therapies with other compounds could broaden treatment efficacy for complex erectile dysfunction cases. Manufacturing process advancements focus on enhanced purity and cost efficiency for generic formulations. Digital health platforms facilitating prescription and adherence represent another significant emerging trend, improving market accessibility and patient engagement in this growing sector.
Global Sildenafil CAS 139755-83-2 Market Regional Analysis
Global Sildenafil CAS 139755-83-2 Market
Trends, by Region

North America Market
Revenue Share, 2025
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North America dominates the global Sildenafil CAS 139755-83-2 market with a substantial 38.2% share. The region's robust pharmaceutical infrastructure, high healthcare expenditure, and strong consumer awareness regarding erectile dysfunction drive this leadership. Favorable regulatory landscapes, significant market penetration of branded and generic Sildenafil, and ongoing research and development contribute to its continued dominance. Major players have a strong presence, leveraging extensive distribution networks and direct-to-consumer marketing strategies. The aging population further fuels demand, cementing North America's pivotal role in the Sildenafil market.
Europe’s sildenafil market is robust, driven by high disposable income and aging populations in Western Europe (Germany, UK, France). Eastern Europe (Poland, Romania) exhibits steady growth due to increasing healthcare access. Regulatory landscapes vary; prescription-only status remains dominant, but growing online pharmacies and telemedicine are reshaping distribution. The market is mature yet dynamic, with generic erosion balanced by lifestyle factors and rising awareness of erectile dysfunction treatments. Competition is intense, with established pharmaceutical giants alongside numerous generic manufacturers. Future growth is tied to further innovation and expanding treatment accessibility across the continent.
The Asia Pacific sildenafil market is experiencing rapid expansion, projected to be the fastest-growing region globally with a remarkable 9.2% CAGR. Key drivers include increasing disposable incomes, rising awareness of erectile dysfunction treatments, and a growing geriatric population across countries like China, India, and Japan. Improved healthcare infrastructure and a shift towards patented and branded medications are further fueling market growth. Local manufacturing capabilities and product accessibility are also significant factors contributing to this dynamic regional market's robust performance.
Latin America's sildenafil market, while smaller than developed regions, is poised for significant growth. Brazil and Mexico lead in market share, driven by increasing awareness of erectile dysfunction (ED), rising disposable incomes, and less stringent regulatory environments compared to some Asian markets. Counterfeit products remain a challenge, but the expanding legal market, coupled with the rising geriatric population and improving healthcare access, particularly in urban centers, presents a lucrative opportunity. Local manufacturing capabilities are also emerging, potentially impacting import reliance. The market is ripe for both established brands and generics.
Middle East & Africa's sildenafil market is characterized by diverse healthcare landscapes. The GCC nations, with higher disposable incomes and developed healthcare infrastructure, exhibit strong growth driven by increasing awareness and private healthcare spending. South Africa also shows significant market penetration due to established pharmaceutical distribution and rising lifestyle diseases. Conversely, North Africa and Sub-Saharan regions face challenges from lower healthcare budgets, limited access to medical facilities, and the prevalence of counterfeit products. However, growing urbanization, improving healthcare access in key cities, and increasing health literacy are expected to fuel future demand across the region, particularly for prescription-based sildenafil.
Top Countries Overview
The United States is a significant consumer and producer in the global sildenafil market. High prevalence of erectile dysfunction, robust healthcare infrastructure, and strong pharmaceutical industry drive demand. Generic competition, regulatory landscape, and public health campaigns notably influence market dynamics within the US and its global trade.
China dominates global sildenafil production providing active pharmaceutical ingredients and finished products. Local manufacturers serve a massive domestic male sexual health market driven by a large aging population and high awareness. Exports are crucial. Counterfeits pose significant challenges impacting both safety and market integrity globally. Strict regulations are increasing.
India is a rapidly growing market for Sildenafil benefiting from increasing health awareness and accessibility. Its large population and rising disposable incomes drive substantial domestic consumption. Local manufacturing capabilities further solidify India's crucial role in the global supply chain for this CAS compound.
Impact of Geopolitical and Macroeconomic Factors
Geopolitical stability impacts sildenafil supply chains, particularly manufacturing hubs in India and China. Regulatory shifts in key markets like the US and Europe regarding API sourcing, intellectual property enforcement, and drug pricing could reshape competitive dynamics. Trade policies and tariffs, especially between major pharmaceutical producing nations, directly influence production costs and accessibility.
Macroeconomic conditions, including inflation and interest rates, affect raw material costs and investment in new production facilities. Healthcare spending trends, driven by aging populations and increasing awareness of erectile dysfunction treatments, provide underlying demand. Exchange rate fluctuations between major currencies also impact profitability for international suppliers.
Recent Developments
- March 2025
Hikma Pharmaceuticals announced the launch of a new, higher-dosage sildenafil citrate tablet in the US market, expanding its generic portfolio. This strategic move aims to capture a larger share of the market for patients requiring stronger treatment options.
- June 2025
Teva Pharmaceuticals and Aurobindo Pharma entered into a strategic partnership to co-develop and co-market a novel sildenafil-based combination therapy for improved efficacy. This collaboration leverages both companies' R&D strengths and market reach.
- August 2024
Torrent Pharmaceuticals completed the acquisition of a regional pharmaceutical company specializing in men's health products in Southeast Asia. This acquisition significantly expands Torrent's market penetration and product offerings in the sildenafil market within that region.
- October 2024
Sandoz initiated a new direct-to-consumer online platform for purchasing generic sildenafil, aiming to improve accessibility and convenience for patients. This strategic initiative directly competes with emerging telehealth providers and offers a streamlined purchasing process.
- January 2025
Pfizer announced a new initiative to combat counterfeit sildenafil products globally through enhanced supply chain security and consumer awareness campaigns. This move aims to protect patient safety and maintain brand integrity in a competitive generic market.
Key Players Analysis
Key players in the Global Sildenafil CAS 1397755-83-2 Market include generic giants like Mylan, Hikma Pharmaceuticals, Sandoz, Teva Pharmaceuticals, and Aurobindo Pharma, who primarily focus on cost effective generic production and distribution leveraging advanced API synthesis and formulation technologies. Indian pharmaceutical leaders such as Torrent Pharmaceuticals, Sun Pharmaceutical Industries, and Cipla are also significant contributors, expanding their global footprint through strategic partnerships and robust manufacturing capabilities. Pfizer, the innovator of Viagra, maintains a presence through its branded product while Recordati plays a niche role in specific regional markets. Strategic initiatives encompass biosimilar development, geographical expansion, and optimizing supply chains, all driven by the increasing demand for erectile dysfunction treatments and patent expiries.
List of Key Companies:
- Mylan
- Hikma Pharmaceuticals
- Sandoz
- Torrent Pharmaceuticals
- Aurobindo Pharma
- Sun Pharmaceutical Industries
- Teva Pharmaceuticals
- Pfizer
- Cipla
- Recordati
- Lupin Pharmaceuticals
- Apotex
- Fresenius Kabi
- Zydus Cadila
- Boehringer Ingelheim
Report Scope and Segmentation
| Report Component | Description |
|---|---|
| Market Size (2025) | USD 2.15 Billion |
| Forecast Value (2035) | USD 3.48 Billion |
| CAGR (2026-2035) | 6.2% |
| Base Year | 2025 |
| Historical Period | 2020-2025 |
| Forecast Period | 2026-2035 |
| Segments Covered |
|
| Regional Analysis |
|
Table of Contents:
List of Figures
List of Tables
Table 1: Global Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 2: Global Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 3: Global Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 4: Global Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 5: Global Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Region, 2020-2035
Table 6: North America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 7: North America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 8: North America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 9: North America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 10: North America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Country, 2020-2035
Table 11: Europe Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 12: Europe Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 13: Europe Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 14: Europe Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 15: Europe Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 16: Asia Pacific Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 17: Asia Pacific Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 18: Asia Pacific Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 19: Asia Pacific Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 20: Asia Pacific Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 21: Latin America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 22: Latin America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 23: Latin America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 24: Latin America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 25: Latin America Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 26: Middle East & Africa Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 27: Middle East & Africa Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Formulation, 2020-2035
Table 28: Middle East & Africa Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Distribution Channel, 2020-2035
Table 29: Middle East & Africa Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 30: Middle East & Africa Sildenafil CAS 139755-83-2 Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
