
Global Proton Pump Inhibitor Injections Market Insights, Size, and Forecast By Indication (Gastroesophageal Reflux Disease, Peptic Ulcer Disease, Zollinger-Ellison Syndrome, Erosive Esophagitis), By Formulation Type (Solution, Lyophilized Powder, Premixed Injection), By End User (Hospitals, Clinics, Homecare Settings), By Route of Administration (Intravenous, Subcutaneous, Intramuscular), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), Key Companies, Competitive Analysis, Trends, and Projections for 2026-2035
Key Market Insights
Global Proton Pump Inhibitor Injections Market is projected to grow from USD 4.2 Billion in 2025 to USD 6.5 Billion by 2035, reflecting a compound annual growth rate of 6.2% from 2026 through 2035. This market encompasses the segment of proton pump inhibitors administered intravenously, primarily used in hospital and critical care settings for patients unable to take oral medication or requiring rapid acid suppression. Key drivers include the rising prevalence of gastroesophageal reflux disease (GERD), peptic ulcers, and other acid related disorders, alongside an increasing number of surgical procedures necessitating perioperative stress ulcer prophylaxis. The growing geriatric population, more susceptible to these conditions and often with comorbidities that impact oral drug absorption, further fuels demand. Additionally, the increasing incidence of critical illnesses and the associated risk of stress induced gastric ulcers contributes significantly to market expansion. Important trends shaping the market include the shift towards biosimilars and generics for cost effectiveness, as well as the exploration of novel formulations with improved pharmacokinetic profiles and reduced side effects. The persistent need for immediate and potent acid suppression in acute clinical scenarios continues to underscore the value of injectable PPIs.
Global Proton Pump Inhibitor Injections Market Value (USD Billion) Analysis, 2025-2035

2025 - 2035
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However, market growth is tempered by several restraints. The expiration of key patent protections for branded PPIs has led to increased generic competition and subsequent price erosion. Stringent regulatory approval processes and the associated time and cost burdens for new product development also pose a challenge. Furthermore, the potential for long term side effects associated with PPI use, such as increased risk of bone fractures and kidney disease, has led to greater scrutiny and a push for more judicious prescribing, particularly for chronic indications. Despite these hurdles, significant opportunities exist for market expansion. The development of next generation PPIs with enhanced efficacy or safety profiles, particularly those addressing current unmet medical needs, presents a strong growth avenue. Expanding into emerging markets, which are experiencing improvements in healthcare infrastructure and rising disposable incomes, offers substantial untapped potential. Furthermore, increased awareness and diagnosis of acid related disorders globally will continue to drive demand for effective treatment options, including injectable formulations.
North America stands as the dominant region in the global PPI injections market, driven by a well-established healthcare system, high prevalence of digestive disorders, advanced diagnostic capabilities, and significant healthcare expenditure. The presence of major pharmaceutical companies and robust research and development activities also contribute to its leading position. Asia Pacific is poised to be the fastest growing region, propelled by improving healthcare access, increasing healthcare expenditure, a large patient pool, and the rising awareness of gastrointestinal diseases. Economic development and the expansion of hospital infrastructure in countries like China and India are key factors supporting this rapid growth. The Hospitals segment leads the market, reflecting the critical need for injectable PPIs in acute care, emergency situations, and surgical settings where rapid symptom relief and ulcer prevention are paramount. Key players like Takeda Pharmaceutical, Dr. Reddy's Laboratories, Fresenius Kabi, Sun Pharmaceutical Industries, AstraZeneca, Pfizer, Teva Pharmaceutical, Amgen, GSK, and Boehringer Ingelheim are actively engaged in competitive strategies including product innovation, geographical expansion, and strategic partnerships to maintain and enhance their market presence.
Quick Stats
Market Size (2025):
USD 4.2 BillionProjected Market Size (2035):
USD 6.5 BillionLeading Segment:
Hospitals (68.4% Share)Dominant Region (2025):
North America (38.2% Share)CAGR (2026-2035):
6.2%
What is Proton Pump Inhibitor Injections?
Proton Pump Inhibitor injections are a medical treatment delivering medications directly into the bloodstream to reduce stomach acid production. These drugs, known as PPIs, work by irreversibly blocking the proton pumps in the stomach’s parietal cells, which are responsible for secreting acid. Administering PPIs via injection is typically reserved for patients who cannot take oral medications, such as those with severe dysphagia, gastrointestinal obstruction, or critical illness. The injectable form ensures rapid absorption and systemic availability, providing quicker relief and effective management for conditions like severe gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome.
What are the Trends in Global Proton Pump Inhibitor Injections Market
Injectable PPIs Rise Beyond Hospital Walls
Tailored Dosing Drives Precision Medicine Adoption
Long Acting Formulations Reshape Patient Care
Combination Therapies Expand Treatment Horizons
Injectable PPIs Rise Beyond Hospital Walls
Injectable PPIs are increasingly administered outside hospitals, reflecting a shift towards broader patient access. Traditionally confined to acute inpatient settings for severe conditions like upper GI bleeds or critically ill patients, these injections are now utilized in outpatient clinics and home care. This expansion beyond hospital walls addresses reflux in patients unable to take oral medication, those with swallowing difficulties, or for short term treatment following discharge, offering greater convenience and continuity of care for managing various acid related disorders.
Tailored Dosing Drives Precision Medicine Adoption
Tailored dosing, enabled by precision medicine, optimizes proton pump inhibitor efficacy and minimizes side effects. Genetic profiling helps determine individual metabolic rates, allowing for personalized dosages. This approach enhances treatment outcomes, drives physician confidence, and accelerates the adoption of injectable PPIs by ensuring patients receive the precise amount of medication needed for their unique physiological make up, improving overall therapeutic management and patient safety.
Long Acting Formulations Reshape Patient Care
Long acting proton pump inhibitor injections are transforming patient care by offering extended drug release. This reduces the frequency of administrations, improving patient adherence and convenience. For chronic conditions requiring consistent medication, these formulations lead to better therapeutic outcomes and a simplified treatment regimen, ultimately enhancing quality of life for individuals needing sustained acid suppression.
Combination Therapies Expand Treatment Horizons
Combination therapies in proton pump inhibitor injections are expanding treatment options for severe acid related disorders. By integrating these injections with other medications, patient outcomes improve, particularly for refractory cases and complex gastrointestinal conditions. This strategy optimizes efficacy, reduces resistance, and enhances therapeutic reach, addressing diverse patient needs more effectively than monotherapy.
What are the Key Drivers Shaping the Global Proton Pump Inhibitor Injections Market
Rising Prevalence of Upper Gastrointestinal Disorders
Advancements in Drug Delivery and Formulations
Expanding Geriatric Population and Associated Conditions
Increased Healthcare Expenditure and Access to Treatment
Rising Prevalence of Upper Gastrointestinal Disorders
The increasing incidence of conditions like gastroesophageal reflux disease, peptic ulcers, and Zollinger-Ellison syndrome fuels demand for proton pump inhibitor injections. These disorders cause severe acid related symptoms requiring rapid, effective treatment. Injections provide immediate relief and are crucial for hospitalized patients or those unable to take oral medication, directly expanding the market for these therapeutics.
Advancements in Drug Delivery and Formulations
Innovations in drug delivery systems and pharmaceutical formulations enhance the efficacy and patient convenience of proton pump inhibitor injections. These advancements include novel sustained release technologies and improved solubility, leading to better absorption and longer lasting effects. This directly drives demand by offering superior treatment options and reducing administration frequency, expanding market reach and adoption.
Expanding Geriatric Population and Associated Conditions
The aging global population significantly drives the proton pump inhibitor injections market. As more individuals reach old age, the prevalence of gastroesophageal reflux disease, peptic ulcers, and other acid related conditions increases. Elderly patients often require injectable PPIs due to swallowing difficulties, malabsorption, or acute hospitalization, fueling demand for these essential medications and expanding the market.
Increased Healthcare Expenditure and Access to Treatment
Rising healthcare spending and broadened access to medical treatments globally fuel the proton pump inhibitor injections market. More individuals can afford and obtain necessary medical care, including advanced interventions requiring PPI injections for gastrointestinal protection or specific therapeutic applications. This expanding patient base directly translates to increased demand for these vital medications.
Global Proton Pump Inhibitor Injections Market Restraints
Stringent Regulatory Hurdles for Novel Injectable Formulations
Developing new injectable proton pump inhibitors faces rigorous regulatory scrutiny. Manufacturers must conduct extensive preclinical and clinical trials to demonstrate safety, efficacy, and quality. This includes detailed assessments of formulation stability, impurity profiles, and bioavailability. The protracted approval processes, coupled with high development costs for meeting these stringent requirements, significantly lengthen market entry timelines. These hurdles create substantial barriers for companies introducing innovative injectable formulations, impacting product availability.
High Development and Manufacturing Costs Limiting Market Entry
Developing and manufacturing proton pump inhibitor injections demands substantial upfront investment. This high cost of research, clinical trials, and production facilities creates a significant barrier for new companies aspiring to enter the global market. The financial outlay required limits the number of potential entrants, concentrating market power among existing players and stifling competition despite the market’s considerable value.
Global Proton Pump Inhibitor Injections Market Opportunities
Acute Care & Critical Settings: Maximizing Injectable PPI Adoption for Non-Oral Patient Segments
In acute care and critical settings, many patients cannot take oral medications due to their condition. This creates a significant opportunity to maximize the adoption of injectable Proton Pump Inhibitors. Focus on patients who are nil per os, intubated, unconscious, or experiencing severe gastrointestinal issues where oral intake is contraindicated or impossible. Promoting the benefits of IV PPIs for stress ulcer prophylaxis, bleeding management, and other indications in these non oral patient segments will drive substantial market growth.
Emerging Markets & Geriatric Populations: Tapping New Growth Frontiers for IV PPIs
The convergence of aging global populations and rapid economic development in emerging markets presents a substantial opportunity for IV PPIs. As life expectancy increases, geriatric patients in regions like Asia Pacific require more intensive acute care for complex gastrointestinal conditions such as bleeding ulcers and severe reflux, often necessitating injectable forms. Improved healthcare access and rising disposable incomes in these growth frontiers enable broader patient reach. Tapping into these expanding demographics, especially the vulnerable elderly needing immediate, effective acid suppression in hospital settings, drives demand and unlocks significant new growth for intravenous proton pump inhibitors.
Global Proton Pump Inhibitor Injections Market Segmentation Analysis
Key Market Segments
By Indication
- •Gastroesophageal Reflux Disease
- •Peptic Ulcer Disease
- •Zollinger-Ellison Syndrome
- •Erosive Esophagitis
By Route of Administration
- •Intravenous
- •Subcutaneous
- •Intramuscular
By Formulation Type
- •Solution
- •Lyophilized Powder
- •Premixed Injection
By End User
- •Hospitals
- •Clinics
- •Homecare Settings
Segment Share By Indication
Share, By Indication, 2025 (%)
- Gastroesophageal Reflux Disease
- Peptic Ulcer Disease
- Erosive Esophagitis
- Zollinger-Ellison Syndrome

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Why are hospitals dominating the Global Proton Pump Inhibitor Injections Market?
Hospitals represent the leading segment due to their crucial role in managing acute gastrointestinal conditions and severe cases requiring immediate and effective acid suppression. Patients presenting with conditions like active upper gastrointestinal bleeding, severe erosive esophagitis, or those unable to take oral medications often receive PPI injections in a hospital setting, supported by round the clock medical supervision and access to specialized equipment, solidifying their substantial market share.
Which indication significantly drives the demand for Proton Pump Inhibitor Injections?
Gastroesophageal Reflux Disease and Peptic Ulcer Disease are major contributors to the demand for PPI injections, especially in their severe or complicated forms. For instance, patients with severe erosive esophagitis or acute upper gastrointestinal bleeding often require rapid and potent acid suppression, which injectable formulations provide more effectively than oral alternatives in the initial treatment phase, making these indications critical drivers for market growth.
Which route of administration is primarily utilized for Proton Pump Inhibitor Injections?
The intravenous route of administration is predominantly favored for Proton Pump Inhibitor injections. This preference stems from the need for rapid onset of action and high bioavailability, crucial for critically ill patients or those with severe gastrointestinal conditions where immediate acid suppression is paramount. While subcutaneous and intramuscular options exist, intravenous administration ensures predictable drug delivery and therapeutic levels, especially in acute care settings.
What Regulatory and Policy Factors Shape the Global Proton Pump Inhibitor Injections Market
The global proton pump inhibitor injection market navigates a complex regulatory landscape. Approval processes are stringent, requiring extensive clinical trials for demonstrating efficacy and safety, overseen by major bodies like the FDA, EMA, and national health authorities worldwide. Good Manufacturing Practices are paramount for injectables, ensuring product sterility and quality standards. Post market surveillance and pharmacovigilance systems track adverse events, maintaining patient safety. Pricing and reimbursement policies, which vary significantly across regions, are critical drivers of market access, influencing product adoption within national healthcare systems. Intellectual property protections and subsequent generic competition also shape the policy environment, impacting innovation and affordability.
What New Technologies are Shaping Global Proton Pump Inhibitor Injections Market?
Innovations are significantly reshaping the global proton pump inhibitor injections market. Emerging technologies prioritize developing ultra long acting formulations, reducing dosing frequency and improving patient adherence. Precision drug delivery systems aim to minimize systemic side effects while maximizing therapeutic impact at the cellular level. Next generation biobetters and novel prodrugs are offering enhanced efficacy profiles and potentially broader applications for severe gastrointestinal conditions. Advanced manufacturing techniques are contributing to more stable, easier to administer injectable products. Personalized medicine approaches are also surfacing, allowing for tailored therapy based on individual patient response, thereby optimizing treatment outcomes and expanding market opportunities for these essential medications.
Global Proton Pump Inhibitor Injections Market Regional Analysis
Global Proton Pump Inhibitor Injections Market
Trends, by Region

North America Market
Revenue Share, 2025
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North America dominates the global proton pump inhibitor (PPI) injections market, holding a substantial 38.2% share. This regional dominance is driven by several factors, including advanced healthcare infrastructure, high prevalence of gastrointestinal disorders requiring injectables, and widespread adoption of innovative treatment options. Favorable reimbursement policies and strong R&D activities by key pharmaceutical players further contribute to the region's leading position. The presence of major market players and a robust healthcare expenditure also propel market growth in North America, making it a pivotal region for PPI injectable therapies.
Europe holds a substantial share in the Global Proton Pump Inhibitor Injections market, driven by its well-established healthcare infrastructure and high prevalence of upper gastrointestinal disorders. Western Europe, particularly Germany, France, and the Kingdom, leads in adoption due to advanced medical facilities and strong reimbursement policies. Eastern European countries are also exhibiting significant growth, albeit from a smaller base, fueled by increasing healthcare expenditure and a rising awareness of effective GI treatments. The region's aging population further contributes to sustained demand for injectable PPIs, making it a key growth engine.
The Asia Pacific Proton Pump Inhibitor (PPI) Injections market is experiencing rapid expansion, projected to be the fastest-growing region with a robust 9.2% CAGR. This surge is driven by increasing healthcare access, a rising prevalence of gastrointestinal disorders like GERD and peptic ulcers requiring immediate intervention, and improving diagnostic capabilities across the region. Countries such as China, India, and Japan are key contributors, investing heavily in healthcare infrastructure and adopting advanced medical treatments. The expanding elderly population, prone to gastrointestinal issues, further fuels market growth, making Asia Pacific a pivotal region for PPI injection manufacturers.
Latin America, though a smaller contributor to the global PPI injections market, exhibits robust growth. Brazil dominates due to its large population and established healthcare infrastructure, witnessing increasing adoption for GI bleed management and perioperative use. Mexico follows, driven by rising healthcare expenditure and awareness. Argentina shows steady expansion. While penetration remains lower than developed regions, increasing hospitalizations for acute GI conditions and improving access to specialized care across the region are key growth drivers. Local manufacturing and distribution networks are also influencing market dynamics, particularly in larger economies.
The Middle East & Africa (MEA) region presents a nascent but growing market for PPI injections. High prevalence of H. pylori infections, GERD, and NSAID-induced ulcers drives demand. Increased awareness, improved healthcare infrastructure, and rising disposable incomes contribute to market expansion. However, affordability remains a barrier in some lower-income countries. Local manufacturing is limited, making the region reliant on imports. Regulatory landscapes vary, impacting market access. Nevertheless, strategic partnerships and expanded distribution networks are fostering growth, particularly in Gulf Cooperation Council (GCC) countries and South Africa, as specialist physician prescribing increases.
Top Countries Overview
The United States plays a significant role in the global proton pump inhibitor injections market. Its advanced healthcare infrastructure, high healthcare spending, and substantial patient population with conditions requiring injectable PPIs contribute to a significant market share and continued growth within the broader global landscape.
China is a significant force in the global proton pump inhibitor injections market. Domestic demand and production drive substantial growth. Chinese companies increasingly innovate and expand their market share globally. This competitive landscape reflects both local consumption and export potential.
India's Global Proton Pump Inhibitor Injections market is expanding due to rising digestive disorders and increased healthcare spending. Its large patient population and growing pharmaceutical industry position it as a significant contributor to market growth and innovation.
Impact of Geopolitical and Macroeconomic Factors
Geopolitical shifts like regional conflicts and trade disputes impact supply chains for API procurement, potentially increasing manufacturing costs and affecting market access for proton pump inhibitor injections. Regulatory changes by influential bodies like the FDA or EMA, or the emergence of stricter local regulations in key markets, significantly influence market entry and product approval timelines for new formulations or generics, creating uncertainty.
Macroeconomic factors such as inflation, currency fluctuations, and interest rate changes directly affect manufacturing expenses, pricing strategies, and affordability for healthcare systems in developing nations. Healthcare budget allocations, influenced by economic growth or recession, dictate procurement volumes and the overall market demand for these critical injections.
Recent Developments
- March 2025
Takeda Pharmaceutical announced a strategic partnership with Amgen to co-develop and co-market a new extended-release formulation of a proton pump inhibitor (PPI) injection. This collaboration aims to leverage Takeda's strong gastroenterology pipeline and Amgen's expertise in drug delivery systems to capture a larger share of the chronic acid reflux market.
- January 2025
Dr. Reddy's Laboratories successfully launched a generic equivalent of a leading branded PPI injection in several key emerging markets. This move is expected to significantly increase accessibility and affordability of injectable PPIs in regions with high unmet medical needs for severe acid-related disorders.
- November 2024
Fresenius Kabi acquired a specialized manufacturing facility from Teva Pharmaceutical, focusing on sterile injectable products including PPIs. This acquisition will enhance Fresenius Kabi's production capacity and supply chain efficiency, particularly for its expanding portfolio of critical care medications.
- February 2025
Sun Pharmaceutical Industries initiated a Phase III clinical trial for a novel, fast-acting intravenous PPI formulation designed for acute gastrointestinal bleeding. This innovation aims to provide quicker symptom relief and better patient outcomes in emergency settings compared to existing injectables.
- April 2025
AstraZeneca announced a strategic initiative to invest heavily in digital health solutions integrated with their PPI injection therapies, including patient monitoring apps and telehealth consultations. This aims to improve patient adherence, track treatment efficacy, and offer personalized care pathways for individuals requiring injectable PPIs.
Key Players Analysis
The global Proton Pump Inhibitor Injections market features key players like Takeda Pharmaceutical, AstraZeneca, and Pfizer, who are pivotal in developing and distributing these essential medications. Companies such as Dr. Reddy's Laboratories and Sun Pharmaceutical Industries are crucial in offering generic versions, enhancing market accessibility. Technologies employed involve advanced drug formulation and sterile manufacturing processes to ensure efficacy and safety. Strategic initiatives include research and development for new indications, expanding geographical reach, and optimizing supply chains. Market growth is driven by the increasing prevalence of gastroesophageal reflux disease, stress induced ulcers, and the rising demand for parenteral administration in critical care settings.
List of Key Companies:
- Takeda Pharmaceutical
- Dr. Reddy's Laboratories
- Fresenius Kabi
- Sun Pharmaceutical Industries
- AstraZeneca
- Pfizer
- Teva Pharmaceutical
- Amgen
- GSK
- Boehringer Ingelheim
- Roche
- Mylan
- Sandoz
- Sanofi
- Novartis
Report Scope and Segmentation
| Report Component | Description |
|---|---|
| Market Size (2025) | USD 4.2 Billion |
| Forecast Value (2035) | USD 6.5 Billion |
| CAGR (2026-2035) | 6.2% |
| Base Year | 2025 |
| Historical Period | 2020-2025 |
| Forecast Period | 2026-2035 |
| Segments Covered |
|
| Regional Analysis |
|
Table of Contents:
List of Figures
List of Tables
Table 1: Global Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 2: Global Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 3: Global Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 4: Global Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 5: Global Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Region, 2020-2035
Table 6: North America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 7: North America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 8: North America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 9: North America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 10: North America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Country, 2020-2035
Table 11: Europe Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 12: Europe Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 13: Europe Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 14: Europe Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 15: Europe Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 16: Asia Pacific Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 17: Asia Pacific Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 18: Asia Pacific Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 19: Asia Pacific Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 20: Asia Pacific Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 21: Latin America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 22: Latin America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 23: Latin America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 24: Latin America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 25: Latin America Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 26: Middle East & Africa Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Indication, 2020-2035
Table 27: Middle East & Africa Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Route of Administration, 2020-2035
Table 28: Middle East & Africa Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Formulation Type, 2020-2035
Table 29: Middle East & Africa Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by End User, 2020-2035
Table 30: Middle East & Africa Proton Pump Inhibitor Injections Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
