
Global MALDI TOF Mass Equipment Market Insights, Size, and Forecast By End Use (Academic Institutions, Pharmaceutical Companies, Research Laboratories, Clinical Laboratories), By Application (Clinical Diagnostics, Pharmaceutical Analysis, Biotechnology Research, Environmental Testing, Food Safety), By Product Type (Compact Mass Spectrometers, High-Throughput Mass Spectrometers, Laboratory Mass Spectrometers), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), Key Companies, Competitive Analysis, Trends, and Projections for 2026-2035
Key Market Insights
Global MALDI TOF Mass Equipment Market is projected to grow from USD 0.78 Billion in 2025 to USD 1.52 Billion by 2035, reflecting a compound annual growth rate of 8.2% from 2026 through 2035. This market encompasses the advanced analytical instruments that utilize Matrix-Assisted Laser Desorption/Ionization (MALDI) coupled with Time-of-Flight (TOF) mass spectrometry for precise molecular analysis. The increasing demand for rapid and accurate diagnostic tools across various sectors is a primary driver. Key market drivers include the rising prevalence of chronic diseases requiring sophisticated diagnostic methods, significant advancements in proteomics and metabolomics research, and the expanding application of MALDI TOF in microbiology for pathogen identification. Furthermore, the growing pharmaceutical and biotechnology industries are heavily investing in these technologies for drug discovery and development, further fueling market expansion. Important trends shaping the market include the miniaturization of MALDI TOF systems, integration with automation platforms, and the development of high-resolution instruments for more detailed molecular characterization. However, high initial capital expenditure for these sophisticated instruments and the need for skilled personnel to operate and maintain them act as significant market restraints, particularly in emerging economies. Despite these challenges, the expanding scope of applications in personalized medicine, food safety, and environmental analysis presents substantial market opportunities for innovation and growth.
Global MALDI TOF Mass Equipment Market Value (USD Billion) Analysis, 2025-2035

2025 - 2035
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North America stands as the dominant region in the global MALDI TOF Mass Equipment Market. This leadership is attributable to a robust healthcare infrastructure, high research and development spending, the presence of major key players, and early adoption of advanced analytical technologies within the pharmaceutical, biotechnology, and clinical sectors. The region benefits from a strong focus on precision medicine and proteomics research, driving the demand for sophisticated mass spectrometry solutions. Conversely, Asia Pacific is identified as the fastest growing region. This rapid growth is propelled by increasing healthcare expenditure, a burgeoning biotechnology industry, rising awareness about advanced diagnostic techniques, and growing government support for research and development activities. The expanding patient pool, coupled with improving economic conditions in countries within the region, fosters an environment conducive to the adoption of advanced analytical instruments like MALDI TOF. The leading application segment is Clinical Diagnostics, which accounts for a substantial share of the market. This segment's dominance is driven by the increasing use of MALDI TOF for rapid microbial identification, biomarker discovery, and clinical research, offering significant advantages in speed and accuracy over traditional methods.
Key players in the global MALDI TOF Mass Equipment Market include Agilent Technologies, Biotage, SCIEX, Waters, Thermo Fisher Scientific, Lumera, Horiba, ABB, and Analytik Jena. These companies are actively engaged in strategic initiatives such as product innovation, mergers and acquisitions, and collaborations to strengthen their market position and expand their product portfolios. For instance, many players are focusing on developing more user-friendly interfaces and automated systems to broaden the adoption of MALDI TOF technology across a wider range of laboratories. Furthermore, strategic alliances with research institutions and diagnostic laboratories are common to foster technological advancements and enhance market penetration. Emphasizing instrument accuracy, speed, and versatility across diverse applications remains a core strategy for maintaining competitiveness and capturing new market segments. The continuous evolution of these instruments, particularly in terms of sensitivity and throughput, is critical for sustained market growth and addressing the evolving needs of end-users across research, clinical, and industrial applications.
Quick Stats
Market Size (2025):
USD 0.78 BillionProjected Market Size (2035):
USD 1.52 BillionLeading Segment:
Clinical Diagnostics (42.5% Share)Dominant Region (2025):
North America (38.2% Share)CAGR (2026-2035):
8.2%
Global MALDI TOF Mass Equipment Market Emerging Trends and Insights
Revolutionizing Clinical Diagnostics with MALDI TOF
Revolutionizing clinical diagnostics with MALDI TOF signifies a transformative shift in disease detection and management. This technology, Matrix Assisted Laser Desorption Ionization Time of Flight, offers unprecedented speed and accuracy in analyzing biological samples. Its power lies in rapid identification of microorganisms, including bacteria and fungi, directly from patient specimens, dramatically reducing turnaround times compared to traditional culture based methods.
Furthermore, MALDI TOF is proving invaluable in oncology, enabling precise characterization of proteins and peptides associated with specific cancer types, facilitating earlier diagnosis and personalized treatment strategies. In toxicology and pharmacology, it delivers swift detection of drugs and metabolites, crucial for therapeutic drug monitoring and forensic investigations. The trend emphasizes moving beyond research applications, embedding MALDI TOF as a standard, high throughput tool in clinical laboratories worldwide, enhancing diagnostic capabilities and improving patient outcomes across a wide spectrum of medical disciplines.
Advancing Omics Research Via Enhanced Mass Spec
The Global MALDI TOF Mass Equipment Market is experiencing a significant trend: advancing omics research via enhanced mass spec. This trend highlights the critical role of sophisticated MALDI TOF technology in pushing the boundaries of proteomics, metabolomics, and lipidomics. Researchers are increasingly relying on these instruments for their superior sensitivity, high resolution, and rapid analysis capabilities. Innovations in ion sources, detectors, and software algorithms are continuously improving the accuracy and depth of data acquired, enabling comprehensive profiling of complex biological samples. This enhancement allows for the identification and quantification of a wider range of biomolecules, driving breakthroughs in biomarker discovery, disease understanding, and drug development. The demand for more powerful and user friendly MALDI TOF systems is thus directly linked to the expanding needs of advanced omics applications.
Accelerating Pharmaceutical Development Through MALDI TOF
Accelerating pharmaceutical development through MALDI TOF is a significant trend transforming drug discovery and analysis. MALDI TOF’s speed and sensitivity are revolutionizing drug candidate screening. It enables rapid analysis of proteins, peptides, and small molecules, crucial for understanding drug interactions and metabolism. Researchers are leveraging its capabilities for high throughput screening of potential therapeutics, quickly identifying promising compounds. Furthermore, MALDI TOF facilitates the characterization of biologics, ensuring quality control and purity. Its application in pharmacokinetics and pharmacodynamics studies provides rapid insights into drug absorption, distribution, metabolism, and excretion. This translates to faster development cycles for new drugs, bringing vital medications to patients more quickly and efficiently. The ability to perform rapid, accurate molecular analysis on a wide range of samples makes MALDI TOF an indispensable tool in modern pharmaceutical R&D, streamlining processes and enhancing productivity across the industry.
What are the Key Drivers Shaping the Global MALDI TOF Mass Equipment Market
Rising Demand for Precise Proteomics and Biomarker Discovery in Drug Development
The increasing need for highly accurate and detailed protein analysis is a major driver for the global MALDI TOF mass equipment market. Drug development critically relies on understanding protein structure, post translational modifications, and interactions to identify novel therapeutic targets and understand disease mechanisms. MALDI TOF offers the sensitivity and high throughput necessary for these complex analyses. Researchers are increasingly utilizing MALDI TOF for precise protein identification, characterization, and quantification across various stages of drug discovery and development. This includes biomarker discovery for disease diagnosis, prognosis, and monitoring treatment efficacy. The demand for robust platforms that can deliver definitive proteomic data and accelerate the identification of new biomarkers fuels the adoption of advanced MALDI TOF instruments, directly expanding the market.
Technological Advancements in MALDI-TOF for Enhanced Speed and Resolution
Technological advancements are a key driver in the MALDI TOF market, propelling the development of instruments with significantly improved speed and resolution. Innovations in laser technology allow for faster sample ionization and data acquisition, leading to higher throughput for demanding applications like drug discovery and clinical diagnostics. Detector improvements, coupled with enhanced data processing algorithms, deliver sharper mass spectra with greater mass accuracy and resolution. This enables scientists to differentiate closely related molecules, identify low abundance analytes, and characterize complex biological samples with unprecedented detail. These continuous upgrades make MALDI TOF more powerful, versatile, and essential for advanced research and routine analysis.
Growing Investment in Clinical Diagnostics and Personalized Medicine
Increasing financial commitments in clinical diagnostics and personalized medicine are significantly propelling the global MALDI TOF mass equipment market. This growth stems from the demand for precise and rapid diagnostic tools capable of analyzing complex biological samples. Investment is channeled into developing new diagnostic tests for early disease detection, treatment monitoring, and identifying biomarkers for personalized therapeutic strategies. MALDI TOF technology offers high throughput and accuracy, making it an ideal platform for these advancements. As healthcare systems globally prioritize tailored patient care and sophisticated diagnostic capabilities, funding for research and development in these areas escalates, directly translating into greater adoption and expansion of MALDI TOF mass spectrometry equipment within laboratories and clinical settings.
Global MALDI TOF Mass Equipment Market Restraints
High Capital Investment and Operational Costs
High capital investment poses a significant barrier for new entrants and smaller players in the global MALDI TOF mass equipment market. The sophisticated technology involved in these instruments demands substantial upfront expenditure for research, development, and manufacturing. Furthermore, acquiring the equipment itself represents a considerable financial commitment for end users, including research institutions and pharmaceutical companies. Beyond initial purchase, operational costs further escalate this restraint. Maintenance contracts, specialized consumables like matrices and target plates, and the need for highly trained personnel to operate and interpret data contribute to ongoing expenses. This continuous financial outlay limits accessibility, particularly for organizations with restricted budgets, thus hindering broader market adoption and growth.
Lack of Standardized Protocols and Regulatory Hurdles
The absence of universally accepted protocols and the complex regulatory landscape significantly impede the global MALDI TOF mass equipment market. Currently, there is no single, harmonized standard for sample preparation, data acquisition, or analysis across different regions and applications. This inconsistency leads to challenges in comparing results between laboratories, validating new methodologies, and ensuring the reproducibility and reliability of data.
Furthermore, varying regulatory requirements across countries for device approval, data handling, and quality control create substantial hurdles for manufacturers. Navigating these diverse and often lengthy approval processes adds considerable time and cost to product development and market entry. Such fragmentation discourages widespread adoption, particularly in clinical diagnostics and drug discovery where stringent regulatory compliance is paramount, ultimately slowing market expansion.
Global MALDI TOF Mass Equipment Market Opportunities
Accelerating Clinical Adoption: MALDI-TOF for Advanced Diagnostics & Personalized Medicine
The opportunity for MALDI TOF in advanced diagnostics and personalized medicine is immense. Its rapid, high throughput capabilities are transforming clinical laboratories worldwide. For advanced diagnostics, MALDI TOF excels in swift microbial identification, significantly reducing turnaround times for infectious disease diagnosis and guiding antibiotic stewardship. It also provides crucial biomarker detection for early disease screening, precise cancer subtyping, and monitoring treatment efficacy. In personalized medicine, the technology enables detailed molecular profiling of patient samples, identifying unique protein and metabolite signatures. This granular data empowers clinicians to tailor therapies, predict drug responses, and optimize patient outcomes, moving beyond a one size fits all approach. The growing demand for efficient and accurate diagnostic solutions, particularly in rapidly expanding healthcare infrastructures like those in Asia Pacific, propels MALDI TOF from a research tool into an essential clinical instrument. Its operational simplicity and robustness further accelerate its widespread adoption in routine hospital settings and reference laboratories, unlocking substantial market expansion.
High-Throughput MALDI-TOF Solutions for Biopharmaceutical R&D and Quality Control
The biopharmaceutical industry urgently requires rapid, reliable analytical tools for drug discovery, development, and stringent quality control. High throughput MALDI TOF solutions directly address this demand by enabling swift, comprehensive characterization of complex biological molecules like proteins, peptides, and glycans across numerous samples.
In research and development, these systems significantly accelerate the identification of therapeutic candidates, monitor critical post translational modifications, and elucidate molecular structures with unprecedented speed, thereby shortening discovery timelines and enhancing experimental efficiency.
For quality control, high throughput MALDI TOF provides indispensable capabilities for rapid impurity profiling, confirming product identity, ensuring batch consistency, and conducting stability studies. This facilitates compliance with rigorous regulatory requirements and allows for faster release of biopharmaceutical products. The ability to process a large volume of samples quickly and accurately positions high throughput MALDI TOF as a crucial enabler for maintaining stringent quality standards throughout the entire biopharmaceutical pipeline, representing a significant market opportunity.
Global MALDI TOF Mass Equipment Market Segmentation Analysis
Key Market Segments
By Application
- •Clinical Diagnostics
- •Pharmaceutical Analysis
- •Biotechnology Research
- •Environmental Testing
- •Food Safety
By Product Type
- •Compact Mass Spectrometers
- •High-Throughput Mass Spectrometers
- •Laboratory Mass Spectrometers
By End Use
- •Academic Institutions
- •Pharmaceutical Companies
- •Research Laboratories
- •Clinical Laboratories
Segment Share By Application
Share, By Application, 2025 (%)
- Clinical Diagnostics
- Pharmaceutical Analysis
- Biotechnology Research
- Environmental Testing
- Food Safety

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Why is Clinical Diagnostics dominating the Global MALDI TOF Mass Equipment Market?
Clinical Diagnostics leads the market primarily due to the rising demand for rapid, accurate, and high-throughput diagnostic tools in healthcare settings. MALDI TOF mass spectrometry offers significant advantages in identifying microorganisms, detecting biomarkers for disease, and supporting personalized medicine initiatives. Its ability to provide quick and reliable results for critical analyses, such as pathogen identification in blood cultures or urinary tract infections, drives its widespread adoption in hospitals and clinical laboratories globally, securing its substantial market share.
How do End Use segments shape the demand for MALDI TOF Mass Equipment?
The End Use segmentation, encompassing Academic Institutions, Pharmaceutical Companies, Research Laboratories, and Clinical Laboratories, highlights the diverse applications driving equipment demand. Pharmaceutical Companies heavily invest in these systems for drug discovery, development, and quality control, leveraging their high throughput capabilities for compound analysis. Academic Institutions and Research Laboratories utilize them for fundamental scientific investigations, protein characterization, and biomarker identification, contributing to continuous innovation and technology adoption across various fields.
What role do different Product Types play in fulfilling market needs?
The market is segmented by Product Type into Compact Mass Spectrometers, High-Throughput Mass Spectrometers, and Laboratory Mass Spectrometers, each catering to specific operational requirements and applications. High-Throughput Mass Spectrometers are indispensable for large-scale screening and analysis in pharmaceutical and biotechnology research, facilitating faster drug development and genomic studies. Conversely, Compact and Laboratory Mass Spectrometers offer versatility and accessibility, making them suitable for routine diagnostic tests, environmental monitoring, and food safety analysis, balancing performance with space and budget considerations.
Global MALDI TOF Mass Equipment Market Regulatory and Policy Environment Analysis
The global MALDI TOF mass equipment market navigates diverse regional regulatory frameworks. In the United States, the Food and Drug Administration governs diagnostic instruments, requiring extensive premarket approval or clearance for clinical applications. European Union regulations, particularly the In Vitro Diagnostic Regulation IVDR, impose stricter requirements for performance evaluation, clinical evidence, and post market surveillance, impacting manufacturers significantly. Asian markets like China and Japan have their own specific national medical device administrations NMPA and MHLW respectively with localized approval pathways. Equipment intended for Research Use Only RUO generally faces fewer immediate regulatory hurdles globally, but its use in diagnostic settings without proper clearance is strictly prohibited. Compliance with ISO 13485 quality management systems is often a prerequisite for market entry. Data privacy laws such as GDPR and HIPAA also influence how these devices handle sensitive patient information. Harmonization efforts by bodies like IMDRF aim to streamline processes, yet regional discrepancies persist, demanding careful strategic planning from manufacturers.
Which Emerging Technologies Are Driving New Trends in the Market?
The global MALDI TOF mass equipment market is witnessing robust growth propelled by continuous innovation. Emerging technologies are significantly enhancing instrument sensitivity and mass resolution, enabling more precise biomarker discovery and identification. Advancements in ion optics, detector design, and data processing algorithms are delivering faster analysis times and higher throughput, critical for clinical microbiology, proteomics, and drug discovery applications. Spatial omics, particularly MALDI imaging, is gaining traction, providing unprecedented insights into molecular distributions within tissues. Miniaturization efforts aim to create more accessible, compact systems. Integration with artificial intelligence and machine learning is revolutionizing data interpretation and predictive analytics, accelerating the identification of novel therapeutic targets and diagnostic markers. These innovations are broadening MALDI TOF’s utility, driving market expansion.
Global MALDI TOF Mass Equipment Market Regional Analysis
Global MALDI TOF Mass Equipment Market
Trends, by Region

North America Market
Revenue Share, 2025
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Dominant Region
North America · 38.2% share
North America stands as the dominant region in the global MALDI TOF Mass Equipment market, commanding a significant 38.2% market share. This leadership is primarily attributed to robust research and development activities across its academic institutions and pharmaceutical companies. High healthcare expenditure and advanced technological infrastructure further fuel market expansion. The presence of key market players and continuous innovation in mass spectrometry applications for clinical diagnostics, proteomics, and drug discovery also contribute substantially to North America’s prominent position. Strong government support for scientific research and a well established biotech sector further solidify its market dominance, driving widespread adoption of MALDI TOF technologies for various analytical needs.
Fastest Growing Region
Asia Pacific · 9.4% CAGR
Asia Pacific stands out as the fastest growing region in the Global MALDI TOF Mass Equipment Market, projecting an impressive CAGR of 9.4% during the forecast period of 2026 to 2035. This accelerated growth is primarily fueled by a surge in research and development activities across the region, particularly in proteomics and drug discovery. Increasing investments in healthcare infrastructure and a rising prevalence of chronic diseases are driving the demand for advanced diagnostic tools like MALDI TOF mass spectrometry. Furthermore, a growing awareness and adoption of sophisticated analytical techniques in pharmaceuticals and biotechnology contribute significantly to this rapid expansion. The region's expanding academic and industrial research base further solidifies its leading position in market growth.
Impact of Geopolitical and Macroeconomic Factors
Geopolitical tensions influence supply chains for specialized components in MALDI TOF mass spectrometers, particularly those sourced from East Asia. Export controls on advanced technologies, driven by national security concerns, could restrict access to cutting edge innovations for manufacturers or end users in certain regions. Furthermore, trade disputes may lead to tariffs, increasing production costs and potentially impacting the affordability of this crucial diagnostic equipment for developing nations. Geopolitical stability is crucial for consistent research collaborations and technology transfer, vital for market advancement.
Macroeconomic factors play a significant role. Healthcare budget constraints in various countries, particularly in Europe, can slow down adoption rates for new equipment. Conversely, increased healthcare spending driven by aging populations and rising cancer diagnoses in emerging economies fuels demand. Inflation affects raw material costs and can lead to higher prices for equipment. Currency fluctuations impact the purchasing power of international buyers and the profitability of manufacturers with global supply chains. Economic growth correlates with increased R&D investment and improved healthcare infrastructure, both boosting market expansion.
Recent Developments
- March 2025
Thermo Fisher Scientific announced a strategic partnership with a leading biopharmaceutical company to develop new MALDI-TOF MS workflows for high-throughput protein characterization. This collaboration aims to accelerate drug discovery and development by integrating advanced mass spectrometry solutions into the biopharmaceutical pipeline.
- July 2024
SCIEX launched a new generation of its MALDI-TOF mass spectrometer, featuring enhanced resolution and sensitivity for complex biological samples. This new instrument is designed to improve throughput and data quality in proteomics, metabolomics, and microbial identification applications.
- September 2024
Agilent Technologies acquired a specialized software company focused on data analysis for mass spectrometry. This acquisition is a strategic move to strengthen Agilent's end-to-end solutions for MALDI-TOF users, offering more integrated and powerful data processing capabilities.
- February 2025
Waters Corporation unveiled a new MALDI-TOF imaging system specifically tailored for pharmaceutical research and clinical diagnostics. This system offers improved spatial resolution and faster acquisition times, enabling more detailed molecular mapping of tissues and enhanced biomarker discovery.
Key Players Analysis
Key players in the Global MALDI TOF Mass Equipment Market like Thermo Fisher Scientific, Waters, and Agilent Technologies dominate with their comprehensive portfolios. Their roles involve developing advanced MALDI TOF instruments utilizing innovations in detector technology and software algorithms. Strategic initiatives include expanding into clinical diagnostics and biopharmaceutical applications, driving market growth through product innovation, and global distribution networks. Companies such as SCIEX and Horiba contribute to specific market niches and technological advancements.
List of Key Companies:
- Aglient Technologies
- Biotage
- SCIEX
- Waters
- Thermo Fisher Scientific
- Lumera
- Agilent Technologies
- Horiba
- ABB
- Analytik Jena
- Bruker
- Shimadzu
- LECO
- PerkinElmer
- MALDI Biotyper
Report Scope and Segmentation
| Report Component | Description |
|---|---|
| Market Size (2025) | USD 0.78 Billion |
| Forecast Value (2035) | USD 1.52 Billion |
| CAGR (2026-2035) | 8.2% |
| Base Year | 2025 |
| Historical Period | 2020-2025 |
| Forecast Period | 2026-2035 |
| Segments Covered |
|
| Regional Analysis |
|
Table of Contents:
List of Figures
List of Tables
Table 1: Global MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 2: Global MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 3: Global MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 4: Global MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Region, 2020-2035
Table 5: North America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 6: North America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 7: North America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 8: North America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Country, 2020-2035
Table 9: Europe MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 10: Europe MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 11: Europe MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 12: Europe MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 13: Asia Pacific MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 14: Asia Pacific MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 15: Asia Pacific MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 16: Asia Pacific MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 17: Latin America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 18: Latin America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 19: Latin America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 20: Latin America MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 21: Middle East & Africa MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 22: Middle East & Africa MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Product Type, 2020-2035
Table 23: Middle East & Africa MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 24: Middle East & Africa MALDI TOF Mass Equipment Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
