
Global Chromatography Instrumentation Market Insights, Size, and Forecast By Application (Pharmaceuticals, Environmental Testing, Food and Beverage, Chemical Processing, Academic Research), By Technique (Gas Chromatography, Liquid Chromatography, Supercritical Fluid Chromatography, Ion Chromatography), By End Use Industry (Healthcare, Food and Beverage, Chemical, Environmental, Academic), By Component (Detector, Column, Pump, Injector, Data Management System), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), Key Companies, Competitive Analysis, Trends, and Projections for 2026-2035
Key Market Insights
Global Chromatography Instrumentation Market is projected to grow from USD 14.8 Billion in 2025 to USD 25.9 Billion by 2035, reflecting a compound annual growth rate of 6.7% from 2026 through 2035. Chromatography instrumentation encompasses a wide array of analytical tools designed for the separation, identification, and quantification of components within complex mixtures. These sophisticated instruments are critical across various scientific disciplines, enabling precise analysis in research, quality control, and process monitoring. The market's growth is primarily driven by the escalating demand for analytical techniques in pharmaceutical and biotechnology industries, particularly for drug discovery, development, and quality assurance. Furthermore, stringent regulatory frameworks worldwide, especially concerning food safety and environmental monitoring, necessitate advanced chromatographic solutions. Technological advancements, such as the miniaturization of instruments, enhanced automation, and improved detection limits, are significantly contributing to market expansion. The versatility of chromatography in addressing diverse analytical challenges across multiple sectors underpins its sustained relevance and growth trajectory.
Global Chromatography Instrumentation Market Value (USD Billion) Analysis, 2025-2035

2025 - 2035
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Several key trends are shaping the chromatography instrumentation landscape. There is a growing emphasis on high-throughput screening and multi-modal analytical platforms to enhance efficiency and data generation in laboratories. The integration of artificial intelligence and machine learning into chromatography workflows is emerging, promising improved data analysis, method development, and predictive capabilities. Additionally, the shift towards green chemistry principles is influencing the development of more sustainable chromatographic methods, reducing solvent consumption and waste generation. However, the market faces restraints such as the high initial cost of advanced chromatography systems and the requirement for skilled personnel to operate and maintain these complex instruments. These factors can particularly impact smaller laboratories and research institutions with limited budgets. Despite these challenges, significant opportunities lie in the expanding applications of chromatography in clinical diagnostics, forensic science, and the analysis of emerging contaminants. The increasing global focus on personalized medicine and biopharmaceutical development also presents substantial avenues for market growth.
North America continues to be the dominant region in the global chromatography instrumentation market. This dominance is attributed to a well-established pharmaceutical and biotechnology sector, significant R&D investments, and the presence of numerous key market players. The region benefits from robust healthcare infrastructure and high adoption rates of advanced analytical technologies. Meanwhile, Asia Pacific is poised to be the fastest-growing region, driven by rapid industrialization, increasing healthcare expenditure, and a burgeoning pharmaceutical and contract research organization industry. The rising awareness regarding food safety and environmental concerns in countries like China and India is also fueling the demand for chromatography instruments. Liquid Chromatography remains the leading segment, holding the largest market share due to its wide applicability in separating heat-sensitive and non-volatile compounds. Key players such as Thermo Fisher Scientific, Waters Corporation, Danaher Corporation, Merck KGaA, and PerkinElmer are employing strategies focused on product innovation, strategic acquisitions, and expanding their global footprint to capitalize on the evolving market dynamics and maintain their competitive edge. Their efforts are concentrated on developing user-friendly, high-performance, and cost-effective solutions to meet the diverse needs of end-users.
Quick Stats
Market Size (2025):
USD 14.8 BillionProjected Market Size (2035):
USD 25.9 BillionLeading Segment:
Liquid Chromatography (45.2% Share)Dominant Region (2025):
North America (38.2% Share)CAGR (2026-2035):
6.7%
What is Chromatography Instrumentation?
Chromatography instrumentation comprises specialized laboratory tools designed to separate, identify, and quantify components within a complex mixture. These instruments facilitate the chromatography process, where a sample passes through a stationary phase with a mobile phase carrying it. This differential interaction leads to separation. Key components often include pumps for precise flow, injectors for reproducible sample introduction, columns containing the stationary phase, detectors for identifying separated components, and data systems for analysis. Its significance lies in its widespread application across various fields, including chemistry, biology, pharmaceuticals, environmental science, and food safety, enabling detailed analysis of substances ranging from simple molecules to complex proteins.
What are the Trends in Global Chromatography Instrumentation Market
AI Driven Chromatography for Enhanced Automation
Portable Miniaturized Chromatography Devices Gain Traction
Sustainability Focused Green Chromatography Solutions
Biopharmaceutical Sector Fuels Specialized Chromatography Demand
AI Driven Chromatography for Enhanced Automation
AI driven chromatography enhances automation by leveraging machine learning algorithms to optimize method development, predict separation outcomes, and control instrumentation autonomously. This leads to increased throughput, improved data quality, and reduced manual intervention across various analytical applications, transforming lab workflows and boosting efficiency in research and industry.
Portable Miniaturized Chromatography Devices Gain Traction
Portable miniaturized chromatography devices are gaining traction due to their ability to provide rapid, on site analysis. These compact instruments offer ease of use and reduced sample volumes, making them ideal for field applications, point of care diagnostics, and research with limited sample availability. Their growing adoption reflects a strong demand for versatile, efficient, and accessible analytical solutions across various industries.
Sustainability Focused Green Chromatography Solutions
Labs seek greener chromatography solutions to reduce environmental impact. This involves developing non toxic solvents, miniaturizing equipment for less waste, and adopting energy efficient instrumentation. Focus is on sustainable reagents and methods, minimizing solvent usage and waste generation. Manufacturers are innovating to meet demand for eco friendly, resource efficient instruments and consumables across all chromatography techniques.
Biopharmaceutical Sector Fuels Specialized Chromatography Demand
Biopharmaceuticals' complex nature demands advanced separation techniques. Increased R&D in biologics, vaccines, and gene therapies drives specialized chromatography for purity, characterization, and quality control. This fuels innovation in high resolution, preparative, and process chromatography systems and consumables, critical for developing and manufacturing these complex therapeutic agents efficiently and safely.
What are the Key Drivers Shaping the Global Chromatography Instrumentation Market
Rising Demand for Analytical Techniques Across Industries
Advancements in Chromatography Instrumentation Technologies
Increasing R&D Investments and Pharmaceutical Pipeline
Stringent Regulatory Standards and Quality Control Requirements
Rising Demand for Analytical Techniques Across Industries
Industries increasingly seek precise data for quality control, research, and development. This surge in analytical needs, from pharmaceuticals to environmental monitoring, necessitates advanced separation and identification methods. Chromatography instruments are essential for meeting these evolving requirements, driving their adoption across diverse sectors.
Advancements in Chromatography Instrumentation Technologies
Innovations in chromatography instrumentation significantly enhance market growth. New technologies offer improved sensitivity, speed, and automation in separating complex mixtures. This leads to more precise and efficient analyses across various industries like pharma and food safety. Advancements include miniaturization, enhanced detectors, and user friendly software, driving greater adoption and expanding application areas for chromatography instruments globally.
Increasing R&D Investments and Pharmaceutical Pipeline
Accelerated pharmaceutical R&D, driven by demand for novel therapeutics, fuels chromatography adoption. Advanced instrumentation is crucial for drug discovery, development, quality control, and pipeline expansion. This necessity for precise analysis and purification of complex biological molecules and synthetic compounds directly propels market growth as companies increase investment in pharmaceutical innovation.
Stringent Regulatory Standards and Quality Control Requirements
Stringent regulatory standards and quality control requirements are propelling the chromatography instrumentation market. Industries like pharmaceuticals, food and beverage, and environmental testing mandate precise analytical techniques to ensure product safety, efficacy, and compliance. These regulations necessitate advanced, reliable chromatography systems for accurate identification, separation, and quantification of compounds, driving increased adoption and technological advancements in the market.
Global Chromatography Instrumentation Market Restraints
High Initial Investment & Operational Costs Limiting Market Penetration
High initial investment and operational costs significantly limit market penetration in the global chromatography instrumentation market. Many potential buyers, particularly smaller laboratories or those in developing regions, find the upfront expenditure for advanced systems and the ongoing maintenance and consumable costs prohibitive. This financial barrier restricts access to valuable chromatographic technologies, hindering broader adoption and market expansion, especially among budget-conscious institutions and emerging economies.
Intensified Competition from Open-Source & DIY Chromatography Solutions
Open source software and DIY hardware solutions present a growing challenge. Hobbyists and academic researchers are increasingly adopting these lower cost alternatives for basic separations. While not matching the performance of high end commercial systems, these accessible tools fulfill many analytical needs. This trend diverts potential customers, particularly those with limited budgets, towards self built or community driven chromatography platforms, thereby intensifying competition for established instrumentation manufacturers.
Global Chromatography Instrumentation Market Opportunities
Precision Medicine & Biopharma Boom: Fueling Demand for Advanced Separation & Characterization
The global boom in precision medicine and biopharmaceutical development is intensely fueling demand for advanced analytical capabilities. This presents a prime opportunity for chromatography instrumentation, especially in rapid growth regions like Asia Pacific. These sophisticated tools are essential for intricate separation and precise characterization of complex biological samples and novel drug modalities. They enable detailed biomarker discovery, quality control, and the development of targeted therapies, driving critical innovation and ensuring the efficacy and safety of next generation biopharmaceuticals worldwide.
AI & Automation Integration: Optimizing Chromatography Workflows for Enhanced Efficiency
Integrating artificial intelligence and automation profoundly enhances chromatography workflows, creating a significant opportunity. This involves developing smart instruments and software solutions that streamline processes, from sample preparation to data analysis. Labs can achieve faster results, reduce human error, and optimize resource utilization. Key areas include AI driven method development, predictive maintenance, and robotic sample handling, which improve overall lab efficiency and productivity. This addresses increasing demand for rapid, accurate analytical insights across all sectors of the global market.
Global Chromatography Instrumentation Market Segmentation Analysis
Key Market Segments
By Technique
- •Gas Chromatography
- •Liquid Chromatography
- •Supercritical Fluid Chromatography
- •Ion Chromatography
By Application
- •Pharmaceuticals
- •Environmental Testing
- •Food and Beverage
- •Chemical Processing
- •Academic Research
By End Use Industry
- •Healthcare
- •Food and Beverage
- •Chemical
- •Environmental
- •Academic
By Component
- •Detector
- •Column
- •Pump
- •Injector
- •Data Management System
Segment Share By Technique
Share, By Technique, 2025 (%)
- Liquid Chromatography
- Gas Chromatography
- Ion Chromatography
- Supercritical Fluid Chromatography

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Why is Liquid Chromatography the leading technique segment in the Global Chromatography Instrumentation Market?
Liquid Chromatography dominates due to its unparalleled versatility and precision in analyzing complex non-volatile and thermally unstable compounds. Its extensive use across various industries, particularly in pharmaceuticals for drug discovery, development, and quality control, as well as in food and beverage for safety and quality analysis, drives its significant adoption. The technique’s ability to separate, identify, and quantify components in a wide range of samples makes it indispensable for applications requiring high sensitivity and accuracy.
What drives the significant demand for chromatography instrumentation within the Pharmaceuticals application segment?
The Pharmaceuticals application segment is a major consumer of chromatography instrumentation due to stringent regulatory requirements for drug purity, potency, and safety. Chromatography techniques are crucial for every stage of pharmaceutical operations, from R&D for synthesizing and characterizing new drug candidates, to quality assurance and quality control for monitoring raw materials, intermediates, and final products. This constant need for precise analytical methods in drug development and manufacturing underpins its substantial market share.
How do components like Detectors and Data Management Systems contribute to the overall value proposition of chromatography instrumentation?
Detectors are critical for identifying and quantifying the separated components, with different types offering varying levels of sensitivity and specificity for diverse analytical needs. The advancement in detector technology directly enhances the performance and utility of chromatography systems. Concurrently, Data Management Systems are increasingly vital, providing sophisticated software for instrument control, data acquisition, processing, analysis, and reporting. These systems enable compliance, improve workflow efficiency, and facilitate complex data interpretation, transforming raw analytical output into actionable insights for users across all end use industries.
What Regulatory and Policy Factors Shape the Global Chromatography Instrumentation Market
The global chromatography instrumentation market is profoundly shaped by stringent regulatory landscapes. Pharmaceutical and biotechnology sectors mandate instruments adhering to GMP, FDA, EMA, and NMPA guidelines for drug development, quality control, and manufacturing, emphasizing method validation and data integrity. Food safety regulations from national and international agencies drive demand for contaminant detection and nutritional analysis. Environmental monitoring necessitates compliance with EPA, REACH, and other regional directives for pollutant identification in air, water, and soil. Clinical diagnostics follow IVD regulations. These policies enforce precision, accuracy, and robust data management, influencing instrument design, software validation, and adoption across all application areas globally.
What New Technologies are Shaping Global Chromatography Instrumentation Market?
The global chromatography instrumentation market thrives on relentless innovation. Miniaturization and enhanced portability are democratizing access, enabling on site and point of care applications. Automation, increasingly powered by artificial intelligence and machine learning, revolutionizes sample preparation, data analysis, and method development, significantly improving efficiency and reproducibility. Emerging advanced detectors offer superior sensitivity, specificity, and multi omics capabilities for complex sample matrices. Hyphenated techniques continue to integrate diverse analytical power, providing comprehensive compound characterization. Furthermore, developments in green chromatography reduce solvent consumption, promoting sustainability. Cloud based data management and predictive analytics are also transforming workflows, driving greater analytical insight and propelling market expansion.
Global Chromatography Instrumentation Market Regional Analysis
Global Chromatography Instrumentation Market
Trends, by Region

North America Market
Revenue Share, 2025
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North America dominates the global chromatography instrumentation market with a 38.2% share. The region's stronghold is fueled by robust R&D activities in biotechnology and pharmaceuticals, particularly in the US. Early adoption of advanced technologies like LC-MS and GC-MS is prominent, driven by strong regulatory frameworks and high demand for analytical testing in food safety and environmental monitoring. Significant investments in life sciences research and well-established academic institutions further contribute to market expansion, fostering continuous innovation and uptake of chromatography solutions across various industries.
Western Europe dominates the European chromatography instrumentation market due to high R&D investments, robust pharmaceutical and biotechnology sectors, and stringent environmental regulations driving demand for analytical testing. Germany, UK, France, and Switzerland are key contributors, boasting established scientific infrastructure and strong academic-industrial collaboration. Eastern Europe, while smaller, shows promising growth, fueled by increasing healthcare spending and industrialization. The region benefits from a large pool of skilled scientists and a strong focus on laboratory modernization. However, pricing pressures and competition from global players remain significant challenges across the continent. Innovation in miniaturization and automation continues to drive market expansion.
The Asia Pacific region is rapidly becoming a powerhouse in the chromatography instrumentation market, exhibiting the highest growth globally with an impressive 9.2% CAGR. This surge is fueled by increasing investments in pharmaceutical and biotechnology research, expanding food safety regulations, and growing environmental concerns across countries like China, India, Japan, and South Korea. Government initiatives promoting domestic manufacturing and rising demand for advanced analytical techniques in various industries further propel market expansion. The region's developing healthcare infrastructure and a burgeoning base of skilled professionals also contribute significantly to this robust growth, making it a key focus for market players.
Latin America presents a dynamic, albeit challenging, market for chromatography instrumentation. Brazil and Mexico lead in market share, driven by robust pharmaceutical, food & beverage, and environmental testing sectors. Government funding for scientific research, particularly in academic and public health institutions, also contributes significantly. However, economic instability, varying regulatory landscapes, and the prevalence of refurbished equipment pose growth constraints. Increased foreign investment, expanding biotech industries, and growing awareness of quality control standards are expected to fuel future demand, particularly for advanced hyphenated techniques. The region remains a strategic focus for manufacturers seeking long-term growth.
The Middle East & Africa chromatography instrumentation market is experiencing robust growth, driven by expanding healthcare infrastructure, rising demand for food safety analysis, and increasing investments in petrochemical and pharmaceutical sectors. Governments are promoting localized drug manufacturing and stricter food quality standards, boosting the adoption of advanced chromatography techniques. Key growth drivers include rising incidence of chronic diseases, increasing environmental concerns, and the need for quality control in various industries. South Africa, Saudi Arabia, and UAE lead the regional market, with significant demand from research institutions and diagnostic laboratories. Future growth is anticipated due to continued industrialization and healthcare modernization initiatives across the region.
Top Countries Overview
The United States dominates the global chromatography instrumentation market, driven by robust R&D, advanced technology, and a strong pharmaceutical and biotech sector. Growing demand in environmental testing, food safety, and clinical diagnostics further fuels market expansion. Innovation remains key for sustained growth.
China is a rapidly growing market for chromatography instruments. Domestic manufacturers are emerging, challenging established international players. Increased R&D investment and demand for quality control in diverse industries are fueling this expansion, making China a key global growth driver.
India's chromatography market is burgeoning. Growing pharmaceutical, biotech, and environmental sectors drive demand for instrumentation. Local manufacturing and research initiatives are increasing. Imports remain significant, with global players dominating, but domestic innovation is slowly gaining traction, promising future growth and market share shifts.
Impact of Geopolitical and Macroeconomic Factors
Geopolitical shifts like trade tensions and regional conflicts disrupt supply chains for raw materials and finished goods, impacting manufacturing costs and market access. Research funding from governments and international bodies, often influenced by political stability and strategic priorities like healthcare innovation, directly shapes market demand, especially for advanced instrumentation. Regulations on environmental monitoring and food safety, varying across nations due to political agendas, further dictate market needs and product development.
Macroeconomic trends such as inflation and interest rate fluctuations influence investment decisions by companies and research institutions, affecting purchasing power for expensive equipment. Economic growth in developing nations fuels demand for chromatography instruments in new markets, driven by expanding pharmaceutical industries and environmental concerns. Currency volatility impacts import export costs and profitability for multinational corporations, while recessions can curb research spending, slowing market expansion.
Recent Developments
- March 2025
Thermo Fisher Scientific announced a strategic initiative to expand its analytical services offerings, specifically focusing on advanced chromatography method development and validation for pharmaceutical and biopharmaceutical clients. This move aims to capture a larger share of the outsourced analytical testing market by leveraging their extensive instrumentation portfolio.
- January 2025
Waters Corporation launched its new 'Empower 4 Chromatography Data System (CDS),' featuring enhanced data processing capabilities and AI-driven insights for improved method optimization and troubleshooting. This next-generation software aims to streamline laboratory workflows and increase data integrity for their global customer base.
- November 2024
Merck KGaA completed the acquisition of 'ChromaSolutions Inc.,' a specialized manufacturer of high-performance liquid chromatography (HPLC) columns and consumables. This acquisition strengthens Merck's position in the chromatography consumables market and expands its product portfolio, particularly in niche application areas.
- July 2024
PerkinElmer announced a partnership with a leading biotechnology startup, 'BioSense Labs,' to co-develop integrated chromatography and mass spectrometry solutions for proteomics research. This collaboration aims to create more sensitive and high-throughput analytical platforms for complex biological samples.
- September 2024
Bruker Corporation unveiled a new compact gas chromatography-mass spectrometry (GC-MS) system, designed for rapid field deployment and on-site analysis in environmental and food safety applications. This product launch targets the growing demand for portable and robust analytical instrumentation outside of traditional laboratory settings.
Key Players Analysis
Key players like Thermo Fisher Scientific and Danaher Corporation dominate the global chromatography instrumentation market through extensive product portfolios covering diverse technologies such as GC, HPLC, and mass spectrometry. Waters Corporation excels in high performance liquid chromatography and ultra performance liquid chromatography, emphasizing innovation for improved resolution and speed. Merck KGaA focuses on consumables and purification solutions, complementing instrument manufacturers. Bruker Corporation and PerkinElmer leverage advanced detection methods and software for complex analytical challenges. Restek Corporation and Phenomenex specialize in columns and sample preparation products, crucial for accurate analysis. Strategic initiatives include acquisitions, R&D investments, and collaborations driving market growth through expanding applications in pharmaceuticals, biotechnology, and environmental testing.
List of Key Companies:
- Merck KGaA
- Waters Corporation
- Restek Corporation
- Danaher Corporation
- Thermo Fisher Scientific
- JASCO
- Bruker Corporation
- PerkinElmer
- KNAUER Wissenschaftliche Gerte
- Phenomenex
- BioRad Laboratories
- S ostensibly Solutions
- AB Sciex
- Agilent Technologies
- GE Healthcare
- Shimadzu Corporation
Report Scope and Segmentation
| Report Component | Description |
|---|---|
| Market Size (2025) | USD 14.8 Billion |
| Forecast Value (2035) | USD 25.9 Billion |
| CAGR (2026-2035) | 6.7% |
| Base Year | 2025 |
| Historical Period | 2020-2025 |
| Forecast Period | 2026-2035 |
| Segments Covered |
|
| Regional Analysis |
|
Table of Contents:
List of Figures
List of Tables
Table 1: Global Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 2: Global Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 3: Global Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 4: Global Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 5: Global Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Region, 2020-2035
Table 6: North America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 7: North America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 8: North America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 9: North America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 10: North America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Country, 2020-2035
Table 11: Europe Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 12: Europe Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 13: Europe Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 14: Europe Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 15: Europe Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 16: Asia Pacific Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 17: Asia Pacific Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 18: Asia Pacific Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 19: Asia Pacific Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 20: Asia Pacific Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 21: Latin America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 22: Latin America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 23: Latin America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 24: Latin America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 25: Latin America Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 26: Middle East & Africa Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Technique, 2020-2035
Table 27: Middle East & Africa Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 28: Middle East & Africa Chromatography Instrumentation Market Revenue (USD billion) Forecast, by End Use Industry, 2020-2035
Table 29: Middle East & Africa Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Component, 2020-2035
Table 30: Middle East & Africa Chromatography Instrumentation Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
