
Global 3D Bioprinting for Tissue and Organ Regeneration Market Insights, Size, and Forecast By End Use (Hospital, Research Institutions, Pharmaceutical Companies, Biotechnology Firms), By Application (Tissue Engineering, Organ Transplantation, Pharmaceutical Testing, Cosmetic Surgery), By Technology (Inkjet Bioprinting, Extrusion Bioprinting, Laser-Assisted Bioprinting, Vat Polymerization), By Material Type (Living Cells, Hydrogels, Biomaterials, Synthetic Polymers), By Region (North America, Europe, Asia-Pacific, Latin America, Middle East and Africa), Key Companies, Competitive Analysis, Trends, and Projections for 2026-2035
Key Market Insights
Global 3D Bioprinting for Tissue and Organ Regeneration Market is projected to grow from USD 3.4 Billion in 2025 to USD 15.7 Billion by 2035, reflecting a compound annual growth rate of 17.4% from 2026 through 2035. This market encompasses the innovative field leveraging additive manufacturing technologies to create functional tissues and organs from living cells and biocompatible materials. Its primary objective is to address the critical shortage of donor organs, improve drug discovery and development, and enable personalized medicine through regenerative therapies. The market is primarily driven by the escalating prevalence of chronic diseases requiring organ transplants, the growing geriatric population susceptible to organ failure, and significant advancements in biotechnology and material science. Increasing research and development funding from both public and private sectors, coupled with a rising demand for patient specific treatment options, further propels market expansion. Moreover, the ethical concerns surrounding animal testing in preclinical studies are shifting focus towards in vitro tissue models created through bioprinting, presenting a substantial driver for adoption across pharmaceutical and cosmetic industries.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Value (USD Billion) Analysis, 2025-2035

2025 - 2035
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Important trends shaping this market include the integration of artificial intelligence and machine learning for optimized bioprinting processes, the development of novel bioinks with enhanced biomechanical and biological properties, and the emergence of multi material bioprinting techniques for creating complex organ structures. However, market growth is tempered by several restraints, including the high cost associated with 3D bioprinting equipment and materials, the stringent regulatory approval processes for bioprinted tissues and organs, and the technical challenges in achieving vascularization and long term functionality of complex bioprinted structures. The ethical considerations surrounding the creation of human tissues and organs also present a notable hurdle. Nevertheless, the market presents immense opportunities driven by the potential for personalized medicine, the development of advanced drug screening platforms, and the eventual creation of fully functional replacement organs.
North America currently holds the dominant position in the global market, primarily due to robust research infrastructure, significant investments in healthcare innovation, the presence of numerous key players, and favorable reimbursement policies for advanced medical procedures. The region also benefits from a high prevalence of chronic diseases and a strong focus on regenerative medicine research. Asia Pacific is poised to be the fastest growing region, attributed to increasing healthcare expenditure, a rapidly expanding patient pool, government initiatives promoting biomedical research, and a growing number of strategic collaborations and partnerships between academic institutions and industry players. Key players such as 3D Biotek, Cellink, Organovo, Xerox, Tevva, Histogen, Poietis, Stratasys, EnvisionTEC, and RegenHU are actively engaged in strategic initiatives including product innovation, geographical expansion, mergers and acquisitions, and collaborations to strengthen their market presence and capitalize on emerging opportunities within the Tissue Engineering segment which currently leads the market. These strategies aim to overcome existing challenges and accelerate the commercialization of bioprinted solutions for various applications.
Quick Stats
Market Size (2025):
USD 3.4 BillionProjected Market Size (2035):
USD 15.7 BillionLeading Segment:
Tissue Engineering (45.8% Share)Dominant Region (2025):
North America (38.7% Share)CAGR (2026-2035):
17.4%
Global 3D Bioprinting for Tissue and Organ Regeneration Market Emerging Trends and Insights
Bioinks Revolutionizing Regenerative Medicine
Bioinks are transforming regenerative medicine, driving a significant trend in global 3D bioprinting. This revolution stems from their crucial role in creating functional tissues and organs. Researchers are developing advanced bioinks, often hydrogel based, with tailored properties like biocompatibility, biodegradability, and mechanical strength. These specialized inks encapsulate living cells, growth factors, and biomolecules, providing a supportive microenvironment for cell proliferation and differentiation. The ability to precisely deposit these cell laden bioinks layer by layer enables the fabrication of complex 3D structures mimicking native tissue architecture. This trend accelerates the development of lab grown organs for transplantation, drug screening platforms, and disease modeling, promising personalized and more effective therapeutic solutions for a range of medical conditions.
Organoids Advancing Therapeutic Discovery
Organoids are revolutionizing therapeutic discovery within global 3D bioprinting. These miniature, lab grown organs, meticulously engineered using patient derived cells and advanced bioprinting techniques, accurately mimic human physiology and disease states. This high fidelity representation allows for unparalleled drug screening, identifying effective compounds and predicting patient responses with greater precision than traditional methods. Researchers can now test novel therapies directly on human relevant models, accelerating the discovery of treatments for a wide range of conditions from neurological disorders to cancer. Furthermore, organoids facilitate personalized medicine by enabling the study of individual patient responses to drugs before clinical administration. This trend significantly reduces preclinical failure rates and streamlines drug development, ultimately bringing life saving therapies to patients faster.
Personalized Bioprinted Scaffolds for Custom Transplants
Personalized bioprinted scaffolds represent a significant advancement. This trend focuses on creating patient specific tissue constructs using 3D bioprinting technology. Instead of generic off the shelf implants, scaffolds are custom designed to match an individual's unique anatomy and cellular requirements. Patient derived cells are often incorporated directly into these bioprinted structures. This bespoke approach minimizes immune rejection and enhances the integration of the transplanted tissue. The goal is to provide perfectly matched replacement tissues or organs for individuals, improving transplant success rates and long term patient outcomes. This customization allows for precise regeneration and functional restoration, moving beyond conventional transplant limitations.
What are the Key Drivers Shaping the Global 3D Bioprinting for Tissue and Organ Regeneration Market
Advancements in Bioprinting Technologies and Bioinks
Advancements in bioprinting technologies and bioinks are a primary driver of the global 3D bioprinting market. Sophisticated bioprinters now offer enhanced precision and resolution, enabling the creation of complex tissue architectures that closely mimic native human organs. Innovations in nozzle design, multi material printing, and integrated imaging systems improve the viability and functionality of printed constructs. Simultaneously, the development of advanced bioinks is crucial. These novel biomaterials possess tunable mechanical properties, improved biocompatibility, and refined cell encapsulation capabilities. Next generation bioinks are designed to deliver crucial growth factors and stimulate specific cellular responses, accelerating tissue maturation and integration. Together, these technological leaps allow for the production of more functional and clinically relevant tissues and organs, addressing critical unmet needs in transplantation and drug discovery. This continuous progress in both hardware and materials fuels the expanding applications and commercial viability of 3D bioprinting.
Increasing Demand for Organ Transplants and Tissue Regeneration
A critical driver in the global 3D bioprinting market for tissue and organ regeneration is the escalating need for organ transplants and advanced tissue repair. Traditional organ donation falls far short of patient demand, leading to extensive waiting lists and significant mortality. Immunosuppression challenges also complicate existing transplant protocols. 3D bioprinting offers a transformative solution by enabling the creation of patient specific, functional tissues and organs, thereby mitigating organ shortages and reducing rejection risks. Furthermore, its application in regenerating damaged or diseased tissues holds immense promise for conditions like burns, spinal cord injuries, and chronic wounds, offering improved patient outcomes and a higher quality of life. This unmet medical need fuels substantial investment and innovation in bioprinting technologies.
Rising R&D Investments and Strategic Collaborations
The global 3D bioprinting market for tissue and organ regeneration is significantly propelled by increasing investments in research and development. Companies and academic institutions are allocating substantial funds to advance bioprinting technologies, explore new biomaterials, and refine cell culture techniques. This financial commitment fosters innovation in printer design, bioink development, and scaffold fabrication methods, leading to more complex and functional tissue constructs. Simultaneously, strategic collaborations between pharmaceutical firms, biotechnology companies, universities, and hospitals are accelerating progress. These partnerships facilitate knowledge sharing, pool resources, and combine diverse expertise, bridging the gap between scientific discovery and clinical application. Such collaborations enable the development of standardized protocols, efficient clinical trials, and ultimately, faster market entry for regenerative therapies.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Restraints
Ethical and Regulatory Hurdles for Bioprinted Organ Implants
Bioprinted organ implants face substantial ethical and regulatory hurdles that significantly restrain market growth. The creation of complex, functional human organs raises profound ethical questions concerning the definition of life, the potential for human enhancement, and the equitable distribution of these advanced medical technologies. Strict regulatory frameworks are essential to ensure the safety and efficacy of these implants, requiring extensive preclinical testing and rigorous clinical trials. Gaining approval from bodies like the FDA or EMA is a lengthy and expensive process due to the novelty and complexity of bioprinted organs. Issues such as long term biocompatibility, potential for immune rejection, and unforeseen side effects in recipients demand meticulous scrutiny. Navigating these intricate ethical considerations and stringent regulatory pathways creates significant delays and increases development costs, slowing market adoption.
High Cost and Limited Accessibility of Advanced 3D Bioprinting Technologies
Advanced 3D bioprinting remains largely inaccessible due to its substantial capital investment and operational expenses. The specialized equipment, sophisticated biomaterials, and highly skilled personnel required for research and clinical applications drive up costs significantly. This financial barrier limits adoption by smaller research institutions, startups, and developing nations, hindering widespread advancement. Furthermore, the limited availability of facilities and trained experts capable of utilizing these complex technologies restricts their deployment beyond well-funded academic and industrial centers. Consequently, a vast potential user base remains underserved, impeding the broader development and application of bioprinted tissues and organs for regeneration worldwide. This high barrier to entry significantly restrains market expansion and global accessibility.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Opportunities
Revolutionizing Organ Transplantation: 3D Bioprinting for Patient-Specific, Functional Organs
The profound opportunity in 3D bioprinting lies in its capacity to fundamentally transform organ transplantation. This technology enables the creation of patient specific, fully functional organs, directly addressing the severe global shortage of donor organs and mitigating the life threatening risk of immunological rejection. By precisely engineering living tissues and cells into complex organ structures, bioprinting offers a personalized medicine solution, moving beyond traditional transplantation limitations. This innovation provides a pathway to on demand organ availability, drastically improving patient outcomes, reducing healthcare costs associated with long term immunosuppression, and enhancing overall quality of life for countless individuals awaiting life saving procedures. The demand for such advanced, personalized medical solutions is immense, particularly in burgeoning healthcare markets like Asia Pacific, where investment in revolutionary therapies is accelerating. This paradigm shift will redefine medical treatment, creating substantial market growth for specialized bioprinting technologies and services.
Accelerating Personalized Medicine: 3D Bioprinting for Advanced In Vitro Disease Modeling and Drug Discovery
This opportunity harnesses 3D bioprinting to create advanced in vitro disease models, fundamentally transforming personalized medicine and drug discovery. By precisely fabricating complex 3D human tissues and organoids, bioprinting overcomes the limitations of traditional 2D cell cultures and animal models. These sophisticated bioprinted constructs offer unparalleled physiological relevance, accurately mimicking human disease progression and drug responses. This enables pharmaceutical companies to screen drug candidates with greater accuracy for efficacy and toxicity, accelerating the identification of promising new therapies. Furthermore, these patient specific models facilitate the development of treatments tailored to individual genetic profiles, directly advancing personalized medicine. This capability shortens drug development timelines, reduces research costs, and significantly improves the success rate in bringing targeted, effective medications to global markets.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Segmentation Analysis
Key Market Segments
By Application
- •Tissue Engineering
- •Organ Transplantation
- •Pharmaceutical Testing
- •Cosmetic Surgery
By Material Type
- •Living Cells
- •Hydrogels
- •Biomaterials
- •Synthetic Polymers
By Technology
- •Inkjet Bioprinting
- •Extrusion Bioprinting
- •Laser-Assisted Bioprinting
- •Vat Polymerization
By End Use
- •Hospital
- •Research Institutions
- •Pharmaceutical Companies
- •Biotechnology Firms
Segment Share By Application
Share, By Application, 2025 (%)
- Tissue Engineering
- Organ Transplantation
- Pharmaceutical Testing
- Cosmetic Surgery

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Why is Tissue Engineering dominating the Global 3D Bioprinting for Tissue and Organ Regeneration Market?
Tissue Engineering holds the largest market share due to its wide applicability in repairing or replacing damaged tissues from various causes, including disease, trauma, and congenital defects. The urgent global demand for regenerative solutions, coupled with significant research and development investments in creating functional tissues like skin, cartilage, and bone, fuels this segment's primary position. Its foundational role in developing prototypes for future organ regeneration also contributes to its leadership.
What technology type is fundamentally driving the innovation in 3D bioprinting?
Extrusion Bioprinting stands out as a critical technology, widely adopted for its versatility and ability to handle a broad range of bioinks with varying viscosities. Its capacity to print relatively large and complex structures layer by layer, accurately depositing cells and biomaterials, makes it indispensable for creating intricate tissue constructs and early-stage organ models. This precision and adaptability are vital for advancing regenerative medicine applications.
Which end user group is pivotal for the initial adoption and development of 3D bioprinting solutions?
Research Institutions are crucial end users, serving as the primary hubs for fundamental research and early stage development in 3D bioprinting. These institutions drive innovation in material science, cell biology, and printing techniques, laying the groundwork for future clinical applications. Their extensive research into novel bioprinting approaches and validation of new constructs is essential for translating laboratory discoveries into practical regenerative therapies.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Regulatory and Policy Environment Analysis
The global 3D bioprinting market for tissue and organ regeneration faces a highly complex and fragmented regulatory environment. Key agencies such as the US FDA, European EMA, and similar bodies in Asia and other regions navigate challenges in classifying bioprinted constructs, often seeing them as combination products integrating medical devices, biologics, and cellular components. This necessitates distinct pathways for approval, demanding rigorous validation of safety, efficacy, and biocompatibility. Ethical considerations surrounding cell sourcing and transplantation further shape policy. The absence of globally harmonized guidelines presents significant hurdles for manufacturers seeking cross border market access. Regulations are still evolving rapidly, attempting to keep pace with technological advancements in biomaterials and cellular science. Government funding and initiatives play a crucial role in shaping policy, encouraging innovation while ensuring patient safety and product quality. This dynamic landscape requires constant monitoring and adaptation by industry players.
Which Emerging Technologies Are Driving New Trends in the Market?
The global 3D bioprinting market for tissue and organ regeneration is experiencing remarkable advancement, propelled by transformative innovations. Emerging technologies are rapidly expanding capabilities, moving beyond basic tissue constructs towards complex, functional organ systems. Advanced bioinks, often incorporating patient specific induced pluripotent stem cells and intelligent biomaterials, are central to improving biocompatibility and structural integrity.
Key breakthroughs include high resolution multi material printing techniques, enabling precise fabrication of intricate vascular networks crucial for larger tissue viability. Artificial intelligence and machine learning are increasingly optimizing print designs and process parameters, accelerating research and development. In situ bioprinting is gaining traction for direct repair within the body. Future innovations focus on scalable vascularization strategies, immune response modulation, and the integration of microfluidics to mimic native biological environments, promising a future of personalized medicine and ultimately addressing the critical organ shortage.
Global 3D Bioprinting for Tissue and Organ Regeneration Market Regional Analysis
Global 3D Bioprinting for Tissue and Organ Regeneration Market
Trends, by Region

North America Market
Revenue Share, 2025
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Dominant Region
North America · 38.7% share
North America stands out as the dominant region in the global 3D Bioprinting for Tissue and Organ Regeneration Market, commanding a substantial 38.7% market share. This leadership is fueled by several key factors. The region boasts a robust ecosystem of advanced research institutions, universities, and biotechnology companies actively engaged in pioneering bioprinting innovations. Significant investment in healthcare infrastructure and research and development initiatives further propels market growth. Early adoption of cutting edge medical technologies and a strong regulatory framework supportive of innovative treatments also contribute to North America's prominent position. The presence of numerous key market players and a high awareness among medical professionals regarding the potential of 3D bioprinting for regenerative medicine solidify its dominance.
Fastest Growing Region
Asia Pacific · 24.8% CAGR
Asia Pacific is poised to be the fastest growing region in the global 3D Bioprinting for Tissue and Organ Regeneration market with an impressive CAGR of 24.8% from 2026 to 2035. This accelerated expansion is fueled by several key factors. Governments across the region are increasingly investing in healthcare infrastructure and research initiatives recognizing the immense potential of regenerative medicine. The rising prevalence of chronic diseases and organ failure further drives demand for innovative solutions like 3D bioprinting. Additionally a growing aging population coupled with increasing disposable incomes is boosting access to advanced medical treatments. The presence of emerging economies actively promoting medical tourism and technological adoption also contributes significantly to this rapid growth trajectory.
Impact of Geopolitical and Macroeconomic Factors
Geopolitical tensions, particularly those impacting research collaborations and global supply chains for specialized biomaterials and reagents, significantly influence market growth. Trade policies, intellectual property rights enforcement across nations, and varying regulatory approval processes for bioprinted tissues and organs create fragmented market access and increase development costs. Furthermore, government funding priorities for regenerative medicine and biofabrication research directly correlate with the pace of innovation and commercialization in different regions. Geopolitical stability is crucial for fostering international partnerships essential for sharing advanced manufacturing techniques and biological data.
Macroeconomic factors, including global inflation, interest rate fluctuations, and healthcare spending trends, shape investment in the 3D bioprinting sector. Economic downturns may lead to reduced R&D budgets from private companies and government agencies, slowing technological advancements. Conversely, rising disposable incomes in developing economies could increase demand for advanced healthcare solutions. Venture capital availability for biotech startups and the overall economic health of key healthcare markets directly impact the market's trajectory, influencing pricing strategies and market penetration.
Recent Developments
- March 2025
Cellink launched a new high-throughput bioprinter designed for industrial-scale tissue engineering and drug discovery applications. This advanced system features multi-material compatibility and automated calibration, significantly accelerating research workflows.
- September 2024
Organovo announced a strategic partnership with a leading pharmaceutical company to develop 3D bioprinted human liver models for toxicity testing. This collaboration aims to reduce reliance on animal testing and provide more accurate predictions of drug efficacy and safety.
- February 2025
3D Biotek successfully completed Phase I clinical trials for its bioprinted cartilage implant for joint repair. The promising results demonstrated safety and early signs of efficacy, paving the way for larger clinical studies.
- July 2024
RegenHU acquired a specialized biomaterials company, enhancing its portfolio of bioinks tailored for complex tissue structures. This acquisition strengthens RegenHU's position as a comprehensive solution provider in the 3D bioprinting market.
Key Players Analysis
Key players like Cellink, Organovo, and Stratasys are driving the global 3D bioprinting market. Cellink and Stratasys lead with their advanced bioprinters and bioinks for tissue engineering. Organovo focuses on therapeutic applications and drug discovery. Their strategic collaborations and continuous R&D in areas like extrusion based and inkjet bioprinting are crucial for market growth, fueled by rising demand for regenerative medicine and personalized therapies.
List of Key Companies:
- 3D Biotek
- Cellink
- Organovo
- Xerox
- Tevva
- Histogen
- Poietis
- Stratasys
- EnvisionTEC
- RegenHU
- Biolife Technologies
- CollPlant
- VivoBio
- Aspect Biosystems
- Allevi
Report Scope and Segmentation
| Report Component | Description |
|---|---|
| Market Size (2025) | USD 3.4 Billion |
| Forecast Value (2035) | USD 15.7 Billion |
| CAGR (2026-2035) | 17.4% |
| Base Year | 2025 |
| Historical Period | 2020-2025 |
| Forecast Period | 2026-2035 |
| Segments Covered |
|
| Regional Analysis |
|
Table of Contents:
List of Figures
List of Tables
Table 1: Global 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 2: Global 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 3: Global 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 4: Global 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 5: Global 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Region, 2020-2035
Table 6: North America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 7: North America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 8: North America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 9: North America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 10: North America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Country, 2020-2035
Table 11: Europe 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 12: Europe 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 13: Europe 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 14: Europe 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 15: Europe 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 16: Asia Pacific 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 17: Asia Pacific 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 18: Asia Pacific 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 19: Asia Pacific 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 20: Asia Pacific 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 21: Latin America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 22: Latin America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 23: Latin America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 24: Latin America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 25: Latin America 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
Table 26: Middle East & Africa 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Application, 2020-2035
Table 27: Middle East & Africa 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Material Type, 2020-2035
Table 28: Middle East & Africa 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Technology, 2020-2035
Table 29: Middle East & Africa 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by End Use, 2020-2035
Table 30: Middle East & Africa 3D Bioprinting for Tissue and Organ Regeneration Market Revenue (USD billion) Forecast, by Country/ Sub-region, 2020-2035
